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GAS41

YEATS domain containing 4

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Gene Name: YEATS domain containing 4
Synonyms: YEATS4, GAS41, Glioma-amplified sequence 41, Glioma-amplified sequence-41, NUBI-1, NuMA binding protein 1, NuMA-binding protein 1, NuBI1, YEATS domain containing 4, YAF9
Target Sequences: NM_006530 NP_006521.1 O95619

Publications (1)

1
Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. Benyu Liu , Liuliu Yang , Xiaoxiao Zhu , Huimu Li, Pingping Zhu, Jiayi Wu, Tiankun Lu, Luyun He, Nian Liu, Shu Meng, Liang Zhou, Buqing Ye, Yong Tian, Zusen Fan. The Journal of experimental medicine. 2019 Nov;216:2653-2668. [Full Text Article] [PubMed:31434684] [PMC:PMC6829595] Related Antibodies: LS-C155530.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
GAS41 (6)
No (6)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (3)
GAS41 Protein - 12.5% SDS-PAGE of human YEATS4 stained with Coomassie Blue
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Wheat Germ Extract
GST
50.71 kDa
2 µg/$439
GAS41 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
GAS41 Protein - Purified recombinant protein YEATS4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
26.3 kDa
20 µg/$1,107
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293T Cells
Myc-DDK (Flag)
26.3 kDa
20 µg/$150
GAS41 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
26.3 kDa
100 µg/$494
GAS41 Protein
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E. coli
His
50 µg/$373; 250 µg/$769; 10 µg/$279; 20 µg/$329; 100 µg/$479; 500 µg/$1,243
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).