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GAPIII / RASA3

RAS p21 protein activator 3

GAPIII / RASA3 is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.

Gene Name: RAS p21 protein activator 3
Synonyms: RASA3, GAPIII, GAP1(IP4BP), GTPase activating protein III, Ins(1,3,4,5)P4-binding protein, GAP1IP4BP, Ins P4-binding protein, RAS p21 protein activator 3
Target Sequences: NM_007368 NP_031394.2 Q14644

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
GAPIII / RASA3 (5)
No (5)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
GAPIII / RASA3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
GAPIII / RASA3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
95.5 kDa
20 µg/$150
GAPIII / RASA3 Protein - 12.5% SDS-PAGE of human RASA3 stained with Coomassie Blue
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Wheat Germ Extract
GST
122.1 kDa
10 µg/$479; 25 µg/$670
GAPIII / RASA3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
95.5 kDa
100 µg/$494
GAPIII / RASA3 Protein - Purified recombinant protein RASA3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
95.5 kDa
20 µg/$1,107
Viewing 1-5 of 5 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).