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GAK
cyclin G associated kinase
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Two transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | cyclin G associated kinase |
| Family/Subfamily: | Protein Kinase , NAK |
| Synonyms: | GAK, Auxilin-2, Cyclin-G-associated kinase, Cyclin G associated kinase, DNAJ26, DNAJC26 |
| Target Sequences: | NM_005255 NP_005246.2 O14976 |
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