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GADD45GIP1 / CRIF1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
| Gene Name: | growth arrest and DNA-damage-inducible, gamma interacting protein 1 |
| Synonyms: | GADD45GIP1, CR6 interacting factor 1, CR6-interacting factor 1, p53-responsive gene 6 protein, PLINP-1, PLINP, Plinp1, CKBBP2, CKII beta binding protein 2, CKII beta-associating protein, CRIF1, PRG6 |
| Target Sequences: | AA149617 Q8TAE8 Q8TAE8 |
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