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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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Additional Contact Details
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GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A receptor subtype. GABA-A receptors are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A receptor is a multimeric subunit complex. To date six alpha, four beta, and four gamma subunits, plus alternative splicing variants of some of these subunits, have been identified. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor.
| Gene Name: | gamma-aminobutyric acid (GABA) A receptor, alpha 1 |
| Family/Subfamily: | Ion Channel , GABA A receptor |
| Synonyms: | GABRA1, GABA A receptor alpha 1, GABA(A) receptor, alpha 1, ECA4, EJM, EJM5 |
| Target Sequences: | NM_000806 NP_000797.2 P14867 |
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