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GABARAP

GABA(A) receptor-associated protein

Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Name: GABA(A) receptor-associated protein
Synonyms: GABARAP, ATG8A, MM46, FLC3B, GABARAP-a
Target Sequences: NM_007278 NP_009209.1 O95166

Publications (2)

1
Chronic ethanol and withdrawal differentially modulate lateral/basolateral amygdala paracapsular and local GABAergic synapses. Diaz MR, Christian DT, Anderson NJ, McCool BA. The Journal of pharmacology and experimental therapeutics. 2011 337:162-70. [PubMed:21209156] [PMC:PMC3063746]
2
Induction of autophagy by Imatinib sequesters Bcr-Abl in autophagosomes and down-regulates Bcr-Abl protein. Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimki KK, Yang XW, Park L, Kwak S, Howland D, Park H, Ellerby LM. American journal of hematology. 2013 [PubMed:23440701] Related Antibodies: LS-C166311.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).