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G6PC / Glucose-6-Phosphatase

glucose-6-phosphatase, catalytic subunit

Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.

Gene Name: glucose-6-phosphatase, catalytic subunit
Synonyms: G6PC, G6Pase-alpha, G6PC1, G-6-Pase, GSD1, Glucose-6-phosphatase alpha, G6Pase, G6PT, Glucose-6-phosphatase, GSD1a
Target Sequences: NM_000151 NP_000142.2 P35575

Publications (1)

1
Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia. Zhang N, Geng T, Wang Z, Zhang R, Cao T, Camporez JP, Cai SY, Liu Y, Dandolo L, Shulman GI, Carmichael GG, Taylor HS, Huang Y. JCI insight. 2018 May;3:pii: 120304. (Mouse) [Full Text Article] [PubMed:29769440] [PMC:PMC6012507]

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G6PC / Glucose-6-Phosphatase (3)
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G6PC / Glucose-6-Phosphatase Protein - 12.5% SDS-PAGE of human G6PC stained with Coomassie Blue
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Wheat Germ Extract
GST, N-terminus
66.9 kDa
2 µg/$439
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40.3 kDa
20 µg/$150
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Myc-DDK (Flag)
40.3 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).