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Unfortunately, the antibody LS-B4009 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



G6PC / Glucose-6-phosphatase Antibodies

glucose-6-phosphatase, catalytic subunit

Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease).

Gene Name: glucose-6-phosphatase, catalytic subunit
Synonyms: G6PC Antibody, G6Pase-alpha Antibody, G6PC1 Antibody, G-6-Pase Antibody, GSD1 Antibody, Glucose-6-phosphatase alpha Antibody, G6Pase Antibody, G6PT Antibody, Glucose-6-phosphatase Antibody, GSD1a Antibody
Target Sequences: NM_000151 NP_000142.2 P35575
 G6PC / Glucose-6-phosphatase Feature Table

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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
G6PC / Glucose-6-phosphatase Rabbit Polyclonal Unconjugated Human IHC-P, WB, Flo aa131-161 No Primary
Anti-G6PC / Glucose-6-phosphatase Antibody (aa131-161) LS-C166302
IHC Image
Flo Image
Rabbit Polyclonal to Human G6PC / Glucose-6-phosphatase
Human
IHC - Paraffin, Western blot, Flow Cytometry
Unconjugated
G6PC / Glucose-6-phosphatase Rabbit Polyclonal Unconjugated Mouse, Human, Rat, Dog WB N-Terminus No Primary
Anti-G6PC / Glucose-6-phosphatase Antibody (N-Terminus) LS-C135157
WB Image
Rabbit Polyclonal to Mouse G6PC / Glucose-6-phosphatase
Mouse, Human, Rat, Dog
Western blot
Unconjugated
G6PC / Glucose-6-phosphatase Rabbit IgG Polyclonal HRP Conjugated, Azide-free Human IHC, WB, Flo, ELISA aa131-161 No Primary
Anti-G6PC / Glucose-6-phosphatase Antibody (aa131-161, Azide-free, HRP) LS-C214451
Rabbit Polyclonal (IgG) to Human G6PC / Glucose-6-phosphatase
Human
IHC, Western blot, Flow Cytometry, ELISA
HRP Conjugated, Azide-free
G6PC / Glucose-6-phosphatase Rabbit IgG Polyclonal PE Conjugated Human IHC, WB, Flo, ELISA aa131-161 No Primary
Anti-G6PC / Glucose-6-phosphatase Antibody (aa131-161, PE) LS-C214452
Rabbit Polyclonal (IgG) to Human G6PC / Glucose-6-phosphatase
Human
IHC, Western blot, Flow Cytometry, ELISA
PE Conjugated
G6PC / Glucose-6-phosphatase Rabbit IgG Polyclonal Unconjugated Human IHC, WB, Flo, ELISA aa131-161 No Primary
Anti-G6PC / Glucose-6-phosphatase Antibody (aa131-161) LS-C321504
Rabbit Polyclonal (IgG) to Human G6PC / Glucose-6-phosphatase
Human
IHC, Western blot, Flow Cytometry, ELISA
Unconjugated
G6PC / Glucose-6-phosphatase Rabbit IgG Polyclonal Biotin Conjugated Human IHC, WB, Flo, ELISA aa131-161 No Primary
Anti-G6PC / Glucose-6-phosphatase Antibody (aa131-161, Biotin) LS-C214450
Rabbit Polyclonal (IgG) to Human G6PC / Glucose-6-phosphatase
Human
IHC, Western blot, Flow Cytometry, ELISA
Biotin Conjugated
G6PC / Glucose-6-phosphatase Rabbit IgG Polyclonal AP Conjugated Human IHC, WB, Flo, ELISA aa131-161 No Primary
Anti-G6PC / Glucose-6-phosphatase Antibody (aa131-161, AP) LS-C214446
Rabbit Polyclonal (IgG) to Human G6PC / Glucose-6-phosphatase
Human
IHC, Western blot, Flow Cytometry, ELISA
AP Conjugated
G6PC / Glucose-6-phosphatase Rabbit IgG Polyclonal APC Conjugated Human IHC, WB, Flo, ELISA aa131-161 No Primary
Anti-G6PC / Glucose-6-phosphatase Antibody (aa131-161, APC) LS-C214448
Rabbit Polyclonal (IgG) to Human G6PC / Glucose-6-phosphatase
Human
IHC, Western blot, Flow Cytometry, ELISA
APC Conjugated
G6PC / Glucose-6-phosphatase Rabbit IgG Polyclonal FITC Conjugated Human IHC, WB, Flo, ELISA aa131-161 No Primary
Anti-G6PC / Glucose-6-phosphatase Antibody (aa131-161, FITC) LS-C214449
Rabbit Polyclonal (IgG) to Human G6PC / Glucose-6-phosphatase
Human
IHC, Western blot, Flow Cytometry, ELISA
FITC Conjugated
Target Corresponding Antibodies
G6PC / Glucose-6-phosphatase
G6PC / Glucose-6-phosphatase Antibody Blocking Peptide - LS-E7779
LS-E7779
G6PC / Glucose-6-phosphatase
LS-C166302
G6PC / Glucose-6-phosphatase
G6PC / Glucose-6-phosphatase Antibody Blocking Peptide - LS-E16247
LS-E16247
G6PC / Glucose-6-phosphatase
Type Target Reactivity Sample Type
Sandwich G6PC / Glucose-6-phosphatase Rat Plasma, Serum, Tissue Homogenates
Rat G6PC / Glucose-6-phosphatase ELISA Kit - LS-F8068
Sandwich
Rat
96-Well Strip Plate with Colorimetric - 450nm detection type
Plasma, Serum, Tissue Homogenates
Sandwich G6PC / Glucose-6-phosphatase Human Cell Lysates, Tissue Homogenates
Human G6PC / Glucose-6-phosphatase ELISA Kit - LS-F9019
Sandwich
Human
96-Well Strip Plate with Colorimetric - 450nm detection type
Cell Lysates, Tissue Homogenates
Sandwich G6PC / Glucose-6-phosphatase Mouse Plasma, Serum, Tissue Homogenates
Mouse G6PC / Glucose-6-phosphatase ELISA Kit - LS-F9366
Sandwich
Mouse
96-Well Strip Plate with Colorimetric - 450nm detection type
Plasma, Serum, Tissue Homogenates

G6PC / Glucose-6-phosphatase Feature Table


Feature Type Location Details
catalytic activity 1 - 357 D-glucose 6-phosphate + H(2)O = D-glucose + phosphate.
Disease 1 - 357 Defects in G6PC are the cause of glycogen storage disease type 1A (GSD1A) [MIM:232200]; also known as von Gierke disease. GSD1A is a metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. GSD1 patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia.
Function 1 - 357 Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
pathway 1 - 357 Carbohydrate biosynthesis; gluconeogenesis.
Similarity 1 - 357 Belongs to the glucose-6-phosphatase family.
Subcellular Location 1 - 357 Endoplasmic reticulum membrane; Multi-pass membrane protein.
web resource 1 - 357 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/G6PC";
arrayexpress 1 - 357 P35575
bgee 1 - 357 P35575
biocyc 1 - 357 MetaCyc:MONOMER-13536
brenda 1 - 357 3.1.3.9
cleanex 1 - 357 HS_G6PC
ctd 1 - 357 2538
doi 1 - 357 10
eggnog 1 - 357 prNOG04436
embl 1 - 357 AK313982
embl 1 - 357 BC130478
embl 1 - 357 BC136369
embl 1 - 357 U01120
ensembl 1 - 357 ENST00000253801
genecards 1 - 357 GC17P041052
geneid 1 - 357 2538
genevestigator 1 - 357 P35575
germonline 1 - 357 ENSG00000131482
go 1 - 357 GO:0004346
go 1 - 357 GO:0006094
go 1 - 357 GO:0030176
go 1 - 357 GO:0042301
go 1 - 357 GO:0042593
hgnc 1 - 357 HGNC:4056
hogenom 1 - 357 HBG443930
hovergen 1 - 357 HBG003560
inparanoid 1 - 357 P35575
interpro 1 - 357 IPR000326
interpro 1 - 357 IPR016275
ipi 1 - 357 IPI00019500
kegg 1 - 357 hsa:2538
medline 1 - 357 20081062
medline 1 - 357 94024015
medline 1 - 357 95349131
medline 1 - 357 95384156
medline 1 - 357 96029267
medline 1 - 357 96311667
medline 1 - 357 97155086
medline 1 - 357 98370999
medline 1 - 357 99140271
medline 1 - 357 99374937
mim 1 - 357 232200
nextbio 1 - 357 10017
oma 1 - 357 YLQVNYQ
orphanet 1 - 357 364
pathway_interaction_db 1 - 357 foxopathway
pathway_interaction_db 1 - 357 hnf3bpathway
pfam 1 - 357 PF01569
pharmgkb 1 - 357 PA28468
phylomedb 1 - 357 P35575
pir 1 - 357 A48251
pirsf 1 - 357 PIRSF000905
proteinmodelportal 1 - 357 P35575
pubmed 1 - 357 10070617
pubmed 1 - 357 10094563
pubmed 1 - 357 10447271
pubmed 1 - 357 10612834
pubmed 1 - 357 10738005
pubmed 1 - 357 10748407
pubmed 1 - 357 10874313
pubmed 1 - 357 11058903
pubmed 1 - 357 11058910
pubmed 1 - 357 12093795
pubmed 1 - 357 12373566
pubmed 1 - 357 14702039
pubmed 1 - 357 15489334
pubmed 1 - 357 15542400
pubmed 1 - 357 16959974
pubmed 1 - 357 19159218
pubmed 1 - 357 7573034
pubmed 1 - 357 7623438
pubmed 1 - 357 7655466
pubmed 1 - 357 8211187
pubmed 1 - 357 8733042
pubmed 1 - 357 9001800
pubmed 1 - 357 9506659
pubmed 1 - 357 9700612
pubmed 1 - 357 9700613
pubmed 1 - 357 9705299
reactome 1 - 357 REACT_15518
reactome 1 - 357 REACT_474
refseq 1 - 357 NP_000142.1
smart 1 - 357 SM00014
string 1 - 357 P35575
supfam 1 - 357 SSF48317
ucsc 1 - 357 uc002icb.1
unigene 1 - 357 Hs.212293
act_site 119 - 119 Proton donor (Potential)
act_site 176 - 176 Nucleophile
binding 83 - 83 Substrate (Potential)
binding 170 - 170 Substrate (Potential)
carbohyd 96 - 96 N-linked (GlcNAc...)
chain 1 - 357 Glucose-6-phosphatase /FTId=PRO_0000087413.
conflict 192 - 192 A -> T (in Ref. 1; AAA16222)
motif 354 - 357 Prevents secretion from ER (Potential)
mutagen 9 - 9 H->A: Partial loss of catalytic activity
mutagen 52 - 52 H->A: Partial loss of catalytic activity
mutagen 76 - 76 K->N: Loss of catalytic activity
mutagen 119 - 119 H->A: Loss of catalytic activity
mutagen 170 - 170 R->Q: Loss of catalytic activity
mutagen 176 - 176 H->A: Loss of catalytic activity
mutagen 179 - 179 H->A: Loss of catalytic activity
mutagen 197 - 197 H->T: Partial loss of catalytic activity
mutagen 252 - 252 H->A: Partial loss of catalytic activity
mutagen 307 - 307 H->A: Partial loss of catalytic activity
mutagen 353 - 353 H->A: Partial loss of catalytic activity
topo_dom 1 - 28 Lumenal (Potential)
topo_dom 50 - 60 Cytoplasmic (Potential)
topo_dom 82 - 117 Lumenal (Potential)
topo_dom 139 - 147 Cytoplasmic (Potential)
topo_dom 169 - 179 Lumenal (Potential)
topo_dom 203 - 209 Cytoplasmic (Potential)
topo_dom 231 - 254 Lumenal (Potential)
topo_dom 276 - 291 Cytoplasmic (Potential)
topo_dom 313 - 320 Lumenal (Potential)
topo_dom 342 - 357 Cytoplasmic (Potential)
transmem 29 - 49 Helical; (Potential)
transmem 61 - 81 Helical; (Potential)
transmem 118 - 138 Helical; (Potential)
transmem 148 - 168 Helical; (Potential)
transmem 180 - 202 Helical; (Potential)
transmem 210 - 230 Helical; (Potential)
transmem 255 - 275 Helical; (Potential)
transmem 292 - 312 Helical; (Potential)
transmem 321 - 341 Helical; (Potential)
variant 5 - 5 M -> R (in GSD1A) /FTId=VAR_046249.
variant 16 - 16 T -> A (in GSD1A) /FTId=VAR_046250.
variant 16 - 16 T -> R (in GSD1A; abolishes enzyme activity as well as reduces enzyme stability). /FTId=VAR_046251.
variant 20 - 20 Q -> R (in GSD1A) /FTId=VAR_009202.
variant 38 - 38 D -> V (in GSD1A) /FTId=VAR_005237.
variant 54 - 54 Q -> P (in GSD1A) /FTId=VAR_009203.
variant 63 - 63 W -> R (in GSD1A) /FTId=VAR_046252.
variant 65 - 65 A -> P (in GSD1A) /FTId=VAR_046253.
variant 68 - 68 G -> R (in GSD1A) /FTId=VAR_046254.
variant 76 - 76 K -> N (in GSD1A) /FTId=VAR_046255.
variant 77 - 77 W -> R (in GSD1A) /FTId=VAR_005238.
variant 81 - 81 G -> R (in GSD1A) /FTId=VAR_009204.
variant 83 - 83 R -> C (in GSD1A; loss of catalytic activity; dbSNP:rs1801175). /FTId=VAR_005239.
variant 83 - 83 R -> H (in GSD1A; dbSNP:rs1801176) /FTId=VAR_005240.
variant 83 - 83 R -> I (in GSD1A) /FTId=VAR_005241.
variant 108 - 108 T -> I (in GSD1A) /FTId=VAR_009205.
variant 110 - 110 E -> K (in GSD1A) /FTId=VAR_005242.
variant 111 - 111 T -> I (in GSD1A) /FTId=VAR_046256.
variant 113 - 113 P -> L (in GSD1A) /FTId=VAR_046257.
variant 116 - 116 P -> L (in a breast cancer sample; somatic mutation). /FTId=VAR_035922.
variant 119 - 119 H -> L (in GSD1A) /FTId=VAR_046258.
variant 122 - 122 G -> D (in GSD1A) /FTId=VAR_046259.
variant 124 - 124 A -> T (in GSD1A) /FTId=VAR_005243.
variant 156 - 156 W -> L (in GSD1A) /FTId=VAR_009206.
variant 166 - 166 V -> A (in GSD1A) /FTId=VAR_046260.
variant 166 - 166 V -> G (in GSD1A) /FTId=VAR_005244.
variant 170 - 170 R -> Q (in GSD1A) /FTId=VAR_046261.
variant 177 - 177 F -> C (in GSD1A) /FTId=VAR_046262.
variant 178 - 178 P -> S (in GSD1A) /FTId=VAR_046263.
variant 179 - 179 H -> P (in GSD1A) /FTId=VAR_046264.
variant 184 - 184 G -> E (in GSD1A) /FTId=VAR_005245.
variant 184 - 184 G -> V (in GSD1A) /FTId=VAR_046265.
variant 188 - 188 G -> D (in GSD1A) /FTId=VAR_009207.
variant 188 - 188 G -> R (in GSD1A) /FTId=VAR_005246.
variant 188 - 188 G -> S (in GSD1A) /FTId=VAR_046266.
variant 209 - 209 Y -> C (in GSD1A; abolishes enzyme activity as well as reduces enzyme stability). /FTId=VAR_046268.
variant 211 - 211 L -> P (in GSD1A) /FTId=VAR_005247.
variant 222 - 222 G -> R (in GSD1A) /FTId=VAR_005248.
variant 236 - 236 W -> R (in GSD1A) /FTId=VAR_046269.
variant 241 - 241 A -> T (in GSD1A) /FTId=VAR_046270.
variant 257 - 257 P -> L (in GSD1A) /FTId=VAR_046271.
variant 264 - 264 N -> K (in GSD1A) /FTId=VAR_046272.
variant 265 - 265 L -> P (in GSD1A) /FTId=VAR_046273.
variant 266 - 266 G -> V (in GSD1A) /FTId=VAR_005249.
variant 270 - 270 G -> R (in GSD1A) /FTId=VAR_046274.
variant 270 - 270 G -> V (in GSD1A) /FTId=VAR_005250.
variant 270 - 270 G -> W (in GSD1A) /FTId=VAR_046275.
variant 295 - 295 R -> C (in GSD1A) /FTId=VAR_005251.
variant 298 - 298 S -> P (in GSD1A) /FTId=VAR_046276.
variant 322 - 322 F -> L (in GSD1A) /FTId=VAR_046277.
variant 327 - 327 Missing (in GSD1A) /FTId=VAR_005252.
variant 338 - 338 V -> F (in GSD1A) /FTId=VAR_005253.
variant 341 - 341 I -> N (in GSD1A) /FTId=VAR_005254.
variant 345 - 345 L -> R (in GSD1A) /FTId=VAR_046278.
keyword 1 - 357 Complete proteome
keyword 1 - 357 Disease mutation
keyword 1 - 357 Endoplasmic reticulum
keyword 1 - 357 Gluconeogenesis
keyword 1 - 357 Glycogen storage disease
keyword 1 - 357 Glycoprotein
keyword 1 - 357 Hydrolase
keyword 1 - 357 Membrane
keyword 1 - 357 Polymorphism
keyword 1 - 357 Transmembrane
keyword 1 - 357 Transmembrane helix
Molecular Weight 1 - 357 40484
1 hit 1 - 357 PF01569

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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