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G3BP1 / G3BP
GTPase activating protein (SH3 domain) binding protein 1
May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.
| Gene Name: | GTPase activating protein (SH3 domain) binding protein 1 |
| Synonyms: | G3BP1, HDH-VIII, G3BP-1, G3BP, GAP binding protein, HDH VIII |
| Target Sequences: | NM_005754 NP_005745.1 Q13283 |
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