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E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
Gene Name: | G2/M-phase specific E3 ubiquitin protein ligase |
Synonyms: | G2E3, KIAA1333, PHD finger protein 7B, PHF7B |
Target Sequences: | NM_017769 NP_060239.2 Q7L622 |
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