FZR1

fizzy/cell division cycle 20 related 1 (Drosophila)

Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

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Proteins (10)

Type

Over-Expression Lysate (6)

Recombinant (4)

Target

FZR1 (10)

Publications

No (10)

Tag

GST (1)

GST, N-terminus (1)

His-SUMO (1)

Myc-DDK (Flag) (7)

Species

Human (7)

Source

293T Cells (3)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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FZR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125686

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.7 kDa

Price:

100 µg/$494

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FZR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125687

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55 kDa

Price:

100 µg/$494

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Human FZR1 Protein (Recombinant GST) (Full Length) - LS-G33735

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

80.08 kDa

Price:

10 µg/$479; 25 µg/$670

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Human FZR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90314

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.7 kDa

Price:

20 µg/$150

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Human FZR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90315

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55 kDa

Price:

20 µg/$150

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Human FZR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90316

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.6 kDa

Price:

20 µg/$150

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Human FZR1 Protein (Recombinant His-SUMO) (Full Length) - LS-G22012

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

70.73 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human FZR1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71665

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.6 kDa

Price:

20 µg/$1,107

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Human FZR1 Protein (Recombinant GST, N-terminus) (aa1-101) - LS-G62457

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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FZR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101409

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.6 kDa

Price:

100 µg/$494

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