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FZR1
fizzy/cell division cycle 20 related 1 (Drosophila)
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
| Gene Name: | fizzy/cell division cycle 20 related 1 (Drosophila) |
| Synonyms: | FZR1, CDC20-like 1b, CDC20-like protein 1, FYR, FZR, FZR2, HCDH, Fizzy-related protein homolog, KIAA1242, CDC20C, Cdh1/Hct1 homolog, HCDH1 |
| Target Sequences: | NM_016263 NP_057347.2 Q9UM11 |
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