Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
|Gene Name:||frizzled class receptor 9|
|Family/Subfamily:||GPCR , Frizzled|
|Synonyms:||FZD9, CD349, Frizzled homolog 9, Fz-9, Frizzled family receptor 9, Frizzled-9, Frizzled 9, Fz9, HFz9, CD349 antigen, Frizzled homolog fzd3, FzE6|
|Target Sequences:||NM_003508 NP_003499.1 O00144|
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