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FZD8 / Frizzled 8

frizzled class receptor 8

Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Gene Name: frizzled class receptor 8
Family/Subfamily: GPCR , Frizzled
Synonyms: FZD8, Frizzled family receptor 8, Frizzled homolog 8, FZ-8, Fz8, Frizzled 8, Frizzled-8, HFZ8
Target Sequences: NM_031866 NP_114072.1 Q9H461

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Products
Antibodies (44)
Primary (44)
FZD8 / Frizzled 8 (44)
Human (41)
Mouse (35)
Rat (31)
Bovine (15)
Chimpanzee (3)
Dog (8)
Horse (7)
Monkey (25)
Rabbit (7)
Xenopus (7)
IHC (27)
IHC-P (23)
WB (19)
ELISA (12)
ICC (1)
IF (4)
Peptide-ELISA (4)
rabbit (40)
goat (3)
rat (1)
Product Group
GPCR Database Antibodies (21)
IHCPlus (19)
PathPlus Cancer (2)
IgG (15)
IgG2a (1)
monoclonal mc (1)
polyclonal pc (43)
AP Conjugated (3)
APC Conjugated (3)
Azide-free (3)
Biotin Conjugated (6)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (19)
N-Terminus (14)
Extracellular Domain (8)
aa144-193 (4)
460-540 aa, C-terminal (1)
C-Terminus (1)
Lys528 (1)
aa24-73 (1)
aa31-80 (1)
aa486-535 (1)
aa684-694 (1)
No (44)
FZD8 / Frizzled 8 Antibody - Anti-FZD8 / Frizzled 8 antibody IHC of human brain, cerebellum, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 8-20 ug/ml.
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FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
FZD8 / Frizzled 8 Antibody - Anti-FZD8 / Frizzled 8 antibody IHC of human brain, cerebellum, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 8-20 ug/ml.
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FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (Extracellular Domain) (Biotin) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100 µl/$650
FZD8 / Frizzled 8 Antibody - Anti-FZD8 / Frizzled 8 antibody IHC of human brain, cerebellum, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 8-20 ug/ml.
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FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (Extracellular Domain) (FITC) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Human, Monkey
IHC, IHC-P
FITC Conjugated
100 µl/$650
FZD8 / Frizzled 8 Antibody - Anti-FZD8 / Frizzled 8 antibody IHC of human brain, cerebellum, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 8-20 ug/ml.
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FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (Extracellular Domain) (AP) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Human, Monkey
IHC, IHC-P
AP Conjugated
100 µl/$650
FZD8 / Frizzled 8 Antibody - Anti-FZD8 / Frizzled 8 antibody IHC of human brain, cerebellum, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 8-20 ug/ml.
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Fast Shipping
FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (Extracellular Domain) (APC) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Human, Monkey
IHC, IHC-P
APC Conjugated
100 µl/$650
FZD8 / Frizzled 8 Antibody - Goat Anti-FZD8 / frizzled 8 Antibody (3µg/ml) staining of paraffin embedded Human Pancreas. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-
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FZD8 / Frizzled 8 Goat anti-Human Polyclonal (aa684-694) Antibody
Mouse, Dog, Bovine, Rat, Human
IHC-P, Peptide-ELISA, WB
Unconjugated
100 µg/$451
FZD8 / Frizzled 8 Antibody - Immunofluorescence analysis of A549 cells, using FZD8 Antibody. The picture on the right is blocked with the synthesized peptide.
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FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (aa31-80) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$306; 100 µl/$366
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FZD8 / Frizzled 8 Rat anti-Mouse Monoclonal (Extracellular Domain) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$420; 500 µg/$856
FZD8 / Frizzled 8 Antibody - Lung, Non Small-Cell Carcinoma
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Cancer
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FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
FZD8 / Frizzled 8 Antibody - Lung, Non Small-Cell Carcinoma
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FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100 µl/$650
FZD8 / Frizzled 8 Antibody - Lung, Non Small-Cell Carcinoma
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Fast Shipping
FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P
FITC Conjugated
100 µl/$650
FZD8 / Frizzled 8 Antibody - Lung, Non Small-Cell Carcinoma
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Fast Shipping
FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) (APC) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P
APC Conjugated
100 µl/$650
FZD8 / Frizzled 8 Antibody - Lung, Non Small-Cell Carcinoma
Select
Fast Shipping
FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) (AP) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P
AP Conjugated
100 µl/$650
FZD8 / Frizzled 8 Antibody - Lung, Non Small-Cell Carcinoma
Select
Fast Shipping
FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) (Azide-free) (HRP) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100 µl/$650
FZD8 / Frizzled 8 Antibody - Lung, Non Small-Cell Carcinoma
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FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) (PE) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P
PE Conjugated
100 µl/$650
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FZD8 / Frizzled 8 Goat anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, WB
Unconjugated
100 µg/$793
FZD8 / Frizzled 8 Antibody - Immunohistochemical analysis of Frizzled 8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$289
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FZD8 / Frizzled 8 Goat anti-Mouse Polyclonal (Biotin) Antibody
Mouse
WB
Biotin Conjugated
50 µg/$819
FZD8 / Frizzled 8 Antibody - Anti-FZD8 / Frizzled 8 antibody IHC of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer
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FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Xenopus, Rat, Horse, Mouse, Bovine, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
FZD8 / Frizzled 8 Antibody - Anti-FZD8 / Frizzled 8 antibody IHC of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Xenopus, Rat, Horse, Mouse, Bovine, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100 µl/$650
FZD8 / Frizzled 8 Antibody - Anti-FZD8 / Frizzled 8 antibody IHC of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Xenopus, Rat, Horse, Mouse, Bovine, Human, Monkey
IHC, IHC-P
FITC Conjugated
100 µl/$650
FZD8 / Frizzled 8 Antibody - Anti-FZD8 / Frizzled 8 antibody IHC of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) (APC) Antibody
Xenopus, Rat, Horse, Mouse, Bovine, Human, Monkey
IHC, IHC-P
APC Conjugated
100 µl/$650
FZD8 / Frizzled 8 Antibody - Anti-FZD8 / Frizzled 8 antibody IHC of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) (Azide-free) (HRP) Antibody
Xenopus, Rat, Horse, Mouse, Bovine, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100 µl/$650
FZD8 / Frizzled 8 Antibody - Anti-FZD8 / Frizzled 8 antibody IHC of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) (PE) Antibody
Xenopus, Rat, Horse, Mouse, Bovine, Human, Monkey
IHC, IHC-P
PE Conjugated
100 µl/$650
FZD8 / Frizzled 8 Antibody - Anti-FZD8 / Frizzled 8 antibody IHC of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
FZD8 / Frizzled 8 Rabbit anti-Human Polyclonal (N-Terminus) (AP) Antibody
Xenopus, Rat, Horse, Mouse, Bovine, Human, Monkey
IHC, IHC-P
AP Conjugated
100 µl/$650
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).