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FZD6 / Frizzled 6
frizzled class receptor 6
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
| Gene Name: | frizzled class receptor 6 |
| Family/Subfamily: | GPCR , Frizzled |
| Synonyms: | FZD6, Frizzled family receptor 6, FZ-6, HFZ6, Frizzled 6, Frizzled-6, Frizzled homolog 6, FZ6, NDNC10 |
| Target Sequences: | NM_003506 NP_003497.2 O60353 |
Publications (2)
1
Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. Bengochea A, de Souza MM, Lefranois L, Le Roux E, Galy O, Chemin I, Kim M, Wands JR, Trepo C, Hainaut P, Scoazec JY, Vitvitski L, Merle P. British journal of cancer. 2008 99:143-50. (IHC-P; Human)
[Full Text Article]
[PubMed:18577996]
[PMC:PMC2453022]
Related Antibodies: LS-A4481.
2
Gene Deconvolution Reveals Aberrant Liver Regeneration and Immune Cell Infiltration in Alcohol-Associated Hepatitis. Adam Kim, Xiaoqin Wu, Daniela S Allende, Laura E Nagy. Hepatology (Baltimore, Md.). 2021 August;74:987-1002. [Full Text Article]
[PubMed:33619773]
[PMC:PMC8475730]
Related Antibodies: LS-A4481.
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FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Cancer
Fast Shipping
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human, Monkey
IHC-P
Unconjugated
50 µg/$440
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (aa116-165) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
100 µl/$515
FZD6 / Frizzled 6 Goat anti-Mouse Polyclonal Antibody
Mouse
ELISA, Flo, IHC, IHC-Pfa, WB
Unconjugated
100 µg/$962
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (aa108-157) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (aa539-588) Antibody
Human
WB
Unconjugated
100 µl/$424
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (90-170 aa, Internal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (aa167-212) Antibody
Mouse, Rat, Human
ICC, IP, WB
Unconjugated
50 µl/$321; 100 µl/$403
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (aa169-214) Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$321; 100 µl/$403
FZD6 / Frizzled 6 Rat anti-Mouse Monoclonal Antibody
Mouse
ELISA, WB
Unconjugated
500 µg/$1,079
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
100 µg/$357
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (aa121-170) Antibody
Human
IF, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (aa493-520) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (aa493-520) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (aa493-520) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (aa493-520) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (aa493-520) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (aa493-520) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
IP, WB
Unconjugated
100 µl/$299
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (aa493-520) Antibody
Human
WB
Unconjugated
400 µl/$393
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