FZD4 / Frizzled 4

frizzled class receptor 4

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

FZD4 / Frizzled 4 (6)

Publications

No (6)

Tag

Fc (1)

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

HEK 293 Cells (1)

Human Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (2)

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Human FZD4 / Frizzled 4 Protein (Recombinant GST, N-terminus) (aa107-206) - LS-G60688

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human FZD4 / Frizzled 4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88867

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.3 kDa

Price:

20 µg/$215

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Human FZD4 / Frizzled 4 Protein (Recombinant Fc) (Met1-Glu180) - LS-G97494

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

43.3 kDa

Price:

50 µg/$483

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Human FZD4 / Frizzled 4 Protein (Recombinant His) (Met1-Glu180) - LS-G97493

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17.7 kDa

Price:

50 µg/$483

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Human FZD4 / Frizzled 4 Protein (Recombinant GST) (Full Length) - LS-G31106

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

86.3 kDa

Price:

10 µg/$479; 25 µg/$670

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FZD4 / Frizzled 4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101049

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.3 kDa

Price:

100 µg/$710

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