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FZD2 / Frizzled 2

frizzled class receptor 2

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Gene Name: frizzled class receptor 2
Family/Subfamily: GPCR , Frizzled
Synonyms: FZD2, Dfrizzled2, Fz2, Frizzled family receptor 2, Frizzled-2, HFz2, Frizzled homolog 2, Fz-2, FzE2, Mfz10, Rfz2, Frizzled 2
Target Sequences: NM_001466 NP_001457.1 Q14332

Publications (1)

1
A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia. Saal HM, Prows CA, Guerreiro I, Donlin M, Knudson L, Sund KL, Chang CF, Brugmann SA, Stottmann RW. Human molecular genetics. 2015 24:3399-409. (WB; Human) [Full Text Article] [PubMed:25759469] [PMC:PMC4834928] Related Antibodies: LS-C166295.

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Proteins (3)
Recombinant (3)
FZD2 / Frizzled 2 (3)
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Fc, C-terminus (2)
GST, N-terminus (1)
Human (1)
Mouse (2)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Low endotoxin level (2)
FZD2 / Frizzled 2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.9kD
10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765
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Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.9 kDa
10 µg/$266; 50 µg/$339
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).