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FXYD4
FXYD domain containing ion transport regulator 4
FXYD4 encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.
| Gene Name: | FXYD domain containing ion transport regulator 4 |
| Family/Subfamily: | Ion Channel Regulator , not assigned-Ion Channel Regulator |
| Synonyms: | FXYD4, CHIF, Channel-inducing factor |
| Target Sequences: | NM_173160 NP_775183.1 P59646 |
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