FURIN

furin (paired basic amino acid cleaving enzyme)

FURIN is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.

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Products

Proteins (13)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (9)

Target

FURIN (13)

Product Group

SARS-CoV-2 Associated Proteins (13)

Publications

No (13)

Tag

GST (1)

His (4)

His, C-Terminal (1)

His, N-Terminal (2)

His-GST (2)

Myc-DDK (Flag) (3)

Species

Human (10)

Mouse (2)

Source

293T Cells (1)

E. coli (6)

HEK 293 Cells (4)

High Five Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

Supernatant (1)

Low Endotoxin Level

Low endotoxin level (1)

Biologically Active

Biologically active (1)

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Human FURIN Protein (Recombinant GST) (Full Length) - LS-G29609

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

110.22 kDa

Price:

10 µg/$479; 25 µg/$670

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Human FURIN Protein (Recombinant His) - LS-G3242

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human FURIN Protein (Recombinant His, C-Terminal) - LS-G476

Source:

High Five Cells

Tag:

His, C-Terminal

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

61.7 kDa

Price:

2 µg/$268; 10 µg/$349

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Human FURIN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75991

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.5 kDa

Price:

20 µg/$150

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Human FURIN Protein (Over-Expression Lysate His, N-Terminal) (Asp108-Glu715) - LS-G96811

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~70 kDa

Price:

100 µg/$298

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Human FURIN Protein (Over-Expression Cell Culture Supernatant His, N-Terminal) (Asp108-Glu715) - LS-G96812

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~70 kDa

Price:

200 µl/$283

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Human FURIN Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65664

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.5 kDa

Price:

20 µg/$1,107

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FURIN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99795

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.5 kDa

Price:

100 µg/$494

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Human FURIN Protein (Recombinant His) (aa105-221) - LS-G14954

Source:

E. coli

Tag:

His

Molecular Weight:

14.3 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Mouse FURIN Protein (Recombinant His-GST) (aa578-734) - LS-G14957

Source:

E. coli

Tag:

His-GST

Molecular Weight:

49.2 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human FURIN Protein (Recombinant His-GST) (aa587-748) - LS-G14959

Source:

E. coli

Tag:

His-GST

Molecular Weight:

49.8 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Mouse FURIN Protein (Recombinant His) (aa418-573) - LS-G14958

Source:

E. coli

Tag:

His

Molecular Weight:

18.9 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human FURIN Protein (Recombinant His) (aa385-500) - LS-G14961

Source:

E. coli

Tag:

His

Molecular Weight:

14.5 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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