FUBP1

far upstream element (FUSE) binding protein 1

FUBP1 is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants.

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ELISA Kits (4)

Type

Custom (2)

Sandwich (2)

Target

FUBP1 (4)

Reactivity

Human (2)

Mouse (1)

Rat (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (3)

Publications

No (4)

Sample Type

Cell Lysates (1)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

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Human FUBP1 (Sandwich ELISA) ELISA Kit - LS-F66737

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

7.8 - 500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Rat FUBP1 (Custom) ELISA Kit - LS-F66311

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Price:

1 Plate/$783

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Mouse FUBP1 (Custom) ELISA Kit - LS-F65947

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$783

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Human FUBP1 (Sandwich ELISA) ELISA Kit - LS-F74293

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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