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FTO

fat mass and obesity associated

Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.

Gene Name: fat mass and obesity associated
Synonyms: FTO, KIAA1752, Protein fto
Target Sequences: Q9C0B1 Q9C0B1

Publications (1)

1
Valproate-Induced Epigenetic Upregulation of Hypothalamic Fto Expression Potentially Linked with Weight Gain. Huan Zhang , Ping Lu , Hui-Ling Tang, Hua-Juan Yan, Wei Jiang, Hang Shi, Si-Yu Chen, Mei-Mei Gao, Xiang-Da Zeng, Yue-Sheng Long. Cellular and molecular neurobiology. 2020 June; [Full Text Article] [PubMed:32500354] Related Antibodies: LS-B5891.

☰ Filters
Antibodies (32)
Proteins (5)
ELISA Kits (3)
Over-Expression Lysate (2)
Primary (32)
Recombinant (3)
Sandwich (3)
FTO (40)
Human (30)
Mouse (20)
Rat (11)
Bovine (5)
Dog (2)
Gibbon (3)
Hamster (3)
Horse (4)
Monkey (4)
Orangutan (3)
Pig (4)
Primate (6)
Rabbit (1)
Sheep (5)
IHC (25)
IHC-P (14)
WB (32)
Flo (1)
ELISA (16)
IF (2)
IP (3)
Peptide-ELISA (3)
rabbit (27)
mouse (4)
goat (1)
Product Group
IHCPlus (3)
IgG (15)
IgG1,k (2)
IgG2a,k (1)
monoclonal mc (4)
polyclonal pc (28)
5-2H10 (1)
AG103 (1)
FT62-6 (1)
FT86-4 (1)
96-Well Strip Plate (3)
APC Conjugated (1)
Biotin Conjugated (3)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (20)
aa1-30 (7)
N-Terminus (5)
C-Terminus (4)
N-Terminal (1)
aa19-68 (1)
aa400-505 (1)
aa464-477 (1)
No (39)
Yes (1)
Plasma (3)
Serum (3)
GST (1)
His, N-Terminal (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (1)
FTO Antibody - Anti-FTO antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FTO Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
50 µl/$460
FTO Antibody - Anti-FTO antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FTO Rabbit anti-Mouse Polyclonal (N-Terminus) (HRP) Antibody
Mouse, Sheep, Bovine, Rat, Hamster, Pig, Horse, Orangutan, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
FTO Antibody - Anti-FTO antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FTO Rabbit anti-Mouse Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Sheep, Bovine, Rat, Hamster, Pig, Horse, Orangutan, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
FTO Antibody - Anti-FTO antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FTO Rabbit anti-Mouse Polyclonal (N-Terminus) (FITC) Antibody
Mouse, Sheep, Bovine, Rat, Hamster, Pig, Horse, Orangutan, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
FTO Antibody - Anti-FTO antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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FTO Mouse anti-Rat Monoclonal (5-2H10) Antibody
Mouse, Dog, Sheep, Bovine, Rat, Horse, Primate, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
FTO Antibody - Immunohistochemical staining of mouse FTO using anti-FTO (mouse), mAb (FT62-6) in mouse tissue (1:500 dilution, 200X). A. Immunoperoxidase staining of formalin-Fixed, paraffin-embedded mouse brain. A-1. Isotype control, mouse brain. B. Immunoperoxidase staining of formalin-Fixed, paraffin-embedded mouse uterus. B-1. Isotype control, mouse uterus.
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FTO Mouse anti-Mouse Monoclonal (FT62-6) Antibody
Mouse
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$354; 100 µg/$407
FTO Antibody - Anti-FTO antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FTO Rabbit anti-Human Polyclonal (aa400-505) Antibody
Mouse, Human, Primate
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
FTO Antibody - Anti-FTO antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FTO Rabbit anti-Human Polyclonal (C-Terminus) (DY550) Antibody
Mouse, Human, Primate
IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
FTO Antibody - Immunohistochemical staining of FTO with anti-FTO (human), mAb (AG103) in brain, hypothalamus and paraventricular nucleus (5~10 ug/ml). This antibody has been tested in immunohistochemistry, analyzed by an anatomic pathologist and validated for use in IHC applications against formalin fixed, paraffin-embedded human tissues. The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain (40x).
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FTO Mouse anti-Human Monoclonal (AG103) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$354; 100 µg/$407
FTO Antibody - Immunohistochemical staining (cytoplasmic) of mouse tissue using anti-FTO (mouse), pAb at 1:500 dilution. . Immunoperoxidase staining of formalin-fixed, paraffin-embedded mouse salivary gland in the presence of control peptide (left) or blocking peptide (right) (200x, brown color).
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FTO Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$323
FTO Antibody - Immunohistochemistry of FTO in mouse brain tissue with FTO antibody at 2.5 ug/mL.
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FTO Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
FTO Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with FTO Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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FTO Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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E. coli
His, N-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
~65kDa (SDS-PAGE)
50 µg/$598; 10 µg/$365
FTO Protein - Purified recombinant protein FTO was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
58.1 kDa
20 µg/$1,107
FTO Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer using FTO Polyclonal Antibody at dilution of 1:60.
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FTO Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
FTO Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using FTO Polyclonal Antibody at dilution of 1:60.
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FTO Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
FTO Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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FTO Rabbit anti-Human Polyclonal (aa1-30) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$952
Select
FTO Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
FTO Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
FTO Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
FTO Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
FTO Antibody - Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FTO antibody at dilution of 1:400
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FTO Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
FTO Antibody - Immunohistochemistry of paraffin-embedded Rat testis using FTO Polyclonal Antibody at dilution of 1:100 (40x lens).
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FTO Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
FTO Antibody - Western blot analysis using anti-FTO (human), mAb (FT86-4) at 1:2000 dilution. 1: Human FTO (His-tagged) (100 ng). 2: Mouse FTO (His-tagged) (100ng). 3: Rat FTO (His-tagged) (100 ng). 4: HEK 293 cell lysate (100 ug). 5: Human Calreticulin (His-tagged) (100ng) (negative control).
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FTO Mouse anti-Human Monoclonal (FT86-4) Antibody
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
50 µg/$337; 100 µg/$386
Viewing 1-25 of 40 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).