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FTCD / 58K Golgi Protein

formimidoyltransferase cyclodeaminase

Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.Binds and promotes bundling of vimentin filaments originating from the Golgi.

Gene Name: formimidoyltransferase cyclodeaminase
Synonyms: FTCD, 58K Golgi Protein, LCHC1
Target Sequences: NM_006657 NP_006648.1 O95954

Publications (8)

1
A novel 58-kDa protein associates with the Golgi apparatus and microtubules. Bloom GS, Brashear TA. The Journal of biological chemistry. 1989 264:16083-92. (ICC, WB; Rat) [PubMed:2777777]
2
Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic. Lippincott-Schwartz J, Cole NB, Marotta A, Conrad PA, Bloom GS. The Journal of cell biology. 1995 128:293-306. [PubMed:7844144] [PMC:PMC2120357]
3
A formiminotransferase cyclodeaminase isoform is localized to the Golgi complex and can mediate interaction of trans-Golgi network-derived vesicles with microtubules. Hennig D, Scales SJ, Moreau A, Murley LL, De Mey J, Kreis TE. The Journal of biological chemistry. 1998 273:19602-11. (ICC) [PubMed:9677386]
4
58K, a microtubule-binding Golgi protein, is a formiminotransferase cyclodeaminase. Bashour AM, Bloom GS. The Journal of biological chemistry. 1998 273:19612-7. (WB; Rat) [PubMed:9677387]
5
Molecular cloning, characterization, and dynamics of rat formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa protein. Gao YS, Alvarez C, Nelson DS, Sztul E. The Journal of biological chemistry. 1998 273:33825-34. (ICC, WB) [PubMed:9837973]
6
A Bpag1 isoform involved in cytoskeletal organization surrounding the nucleus. Young KG, Pinheiro B, Kothary R. Experimental cell research. 2006 312:121-34. [PubMed:16289082]
7
Mutation in the DC-SIGN cytoplasmic triacidic cluster motif markedly attenuates receptor activity for phagocytosis and endocytosis of mannose-containing ligands by human myeloid cells. Azad AK, Torrelles JB, Schlesinger LS. Journal of leukocyte biology. 2008 84:1594-603. [PubMed:18772280] [PMC:PMC2614595]
8
Differential effects of exogenous and autocrine growth hormone on LNCaP prostate cancer cell proliferation and survival. Gittenberger-de Groot AC, Mahtab EA, Hahurij ND, Wisse LJ, Deruiter MC, Wijffels MC, Poelmann RE. Journal of cellular biochemistry. 2012 (ICC; Human) [PubMed:23238889]
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Proteins (6)
Over-Expression Lysate (4)
Recombinant (2)
FTCD / 58K Golgi Protein (6)
No (6)
GST, N-terminus (1)
Myc-DDK (Flag) (5)
Human (4)
293T Cells (2)
HEK 293 Cells (3)
Wheat Germ Extract (1)
FTCD / 58K Golgi Protein Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Human FTCD / 58K Golgi Protein (Recombinant GST, N-terminus) (aa440-541) - LS-G61657
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
FTCD / 58K Golgi Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
FTCD / 58K Golgi Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115164
HEK 293 Cells
Myc-DDK (Flag)
58.7 kDa
100 µg/$494
FTCD / 58K Golgi Protein Protein - Purified recombinant protein FTCD was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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Human FTCD / 58K Golgi Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69684
HEK 293 Cells
Myc-DDK (Flag)
58.7 kDa
20 µg/$1,107
FTCD / 58K Golgi Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human FTCD / 58K Golgi Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85262
293T Cells
Myc-DDK (Flag)
58.7 kDa
20 µg/$150
FTCD / 58K Golgi Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human FTCD / 58K Golgi Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85263
293T Cells
Myc-DDK (Flag)
58.7 kDa
20 µg/$215
FTCD / 58K Golgi Protein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
FTCD / 58K Golgi Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102902
HEK 293 Cells
Myc-DDK (Flag)
58.7 kDa
100 µg/$710
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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