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FSTL3 / FLRG

Follistatin-like 3 (secreted Glycoprotein)

Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.

Gene Name: Follistatin-like 3 (secreted Glycoprotein)
Synonyms: FSTL3, FLRG, Follistatin-related protein 3, Follistatin-like protein 3, FSRP
Target Sequences: NM_005860 NP_005851.1 O95633

Publications (2)

1
Prognostic value of follistatin-like 3 in human invasive breast cancer. Couto HL, Buzelin MA, Toppa NH, Bloise E, Wainstein AJ, Reis FM. Oncotarget. 2017 June;8:42189-42197. (Human) [Full Text Article] [PubMed:28178680] [PMC:PMC5522059] Related Antibodies: LS-C166265.
2
Inhibition of FSTL3 abates the proliferation and metastasis of renal cell carcinoma via the GSK-3ß/ß-catenin signaling pathway. Fengfeng Sun, Peng Sun, Xiaofeng Yang, Liangliang Hu, Jianguo Gao, Tao Tian. Aging. 2021 Sep;13:22528-22543. [Full Text Article] [PubMed:34555811] [PMC:PMC8507290] Related Antibodies: LS-C166265.

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
FSTL3 / FLRG (7)
No (7)
GST (1)
GST, N-terminus + His, C-terminus (1)
His (1)
His-S (1)
Myc-DDK (Flag) (3)
Human (4)
Mouse (2)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Human Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (1)
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293T Cells
Myc-DDK (Flag)
27.66 kDa
20 µg/$150
FSTL3 / FLRG Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
27.66 kDa
100 µg/$494
FSTL3 / FLRG Protein
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E. coli
GST, N-terminus + His, C-terminus
55.7 kDa
50 µg/$419
FSTL3 / FLRG Protein - Recombinant Follistatin Like Protein 3 By SDS-PAGE
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E. coli
His-S
28.6 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
FSTL3 / FLRG Protein - 12.5% SDS-PAGE of human FSTL3 stained with Coomassie Blue
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Wheat Germ Extract
GST
51.7 kDa
10 µg/$479; 25 µg/$670
FSTL3 / FLRG Protein - Purified recombinant protein FSTL3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
24.9 kDa
20 µg/$1,107
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
26 kDa
50 µg/$721
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).