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FSTL3 / FLRG
Follistatin-like 3 (secreted Glycoprotein)
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
| Gene Name: | Follistatin-like 3 (secreted Glycoprotein) |
| Synonyms: | FSTL3, FLRG, Follistatin-related protein 3, Follistatin-like protein 3, FSRP |
| Target Sequences: | NM_005860 NP_005851.1 O95633 |
Publications (2)
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