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FRK

fyn-related kinase

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Gene Name:	fyn-related kinase
Family/Subfamily:	Protein Kinase , Src
Synonyms:	FRK, BSK/IYK, BSK, Fyn-related kinase, GTK, PTK5 protein tyrosine kinase 5, RAK, Tyrosine-protein kinase FRK, Protein-tyrosine kinase 5, PTK5
Target Sequences:	NM_002031 NP_002022.1 P42685

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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