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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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FRK

fyn-related kinase

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Gene Name: fyn-related kinase
Family/Subfamily: Protein Kinase , Src
Synonyms: FRK, BSK/IYK, BSK, Fyn-related kinase, GTK, PTK5 protein tyrosine kinase 5, RAK, Tyrosine-protein kinase FRK, Protein-tyrosine kinase 5, PTK5
Target Sequences: NM_002031 NP_002022.1 P42685

Filtered By: None
Target
FRK (56)
Reactivity
Human (45)
Mouse (25)
Rat (12)
Chimpanzee (3)
Dog (4)
Gibbon (6)
Guinea pig (4)
Monkey (8)
Pig (8)
Rabbit (4)
Application
IHC (29)
IHC-P (8)
WB (47)
Flo (5)
ELISA (22)
ICC (3)
IF (10)
Peptide-ELISA (3)
Host
rabbit (46)
mouse (9)
rat (1)
Isotype
IgG (40)
IgG1 (9)
Clonality
monoclonal mc (9)
polyclonal pc (47)
Clone
1A8H2C12 (1)
3E2 (1)
40 (1)
5F3 (1)
5G4 (1)
6D2 (1)
7A7 (1)
7H3 (1)
Format
AP Conjugated (2)
APC (1)
APC Conjugated (3)
Azide-free (2)
Biotin Conjugated (6)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (6)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (29)
Epitope
aa234-491 (10)
aa464-491 (8)
N-Terminus (7)
aa218-267 (4)
aa35-84 (4)
aa476-509 (2)
40-120 aa, Internal (1)
Asn103 (1)
Internal (1)
aa1-107 (1)
aa482-516 (1)
aa71-120 (1)
Publications
No (56)
Showing 1-25 of 56 results

FRK Antibody (clone 1A8H2C12) IHC-plus™ LS-B4095
Mouse Monoclonal [clone 1A8H2C12] (IgG1) to Human FRK
Human
ELISA IHC IHC-P WB
Unconjugated
50µl  $425.00
Anti-FRK antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-FRK antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-FRK antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-FRK antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.

FRK Antibody (clone 6D2) LS-C114623
Mouse Monoclonal [clone 6D2] (IgG1) to Human FRK
Human
Flo IF IHC IHC-P WB
Unconjugated
100µl  $335.00
IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-FRK mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded colon tissue using anti-FRK mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-FRK mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded colon tissue using anti-FRK mouse monoclonal antibody. (Dilution 1:50).

FRK Antibody (clone 5G4) LS-C114622
Mouse Monoclonal [clone 5G4] (IgG1) to Human FRK
Human
Flo IF IHC IHC-P WB
Unconjugated
100µl  $345.00
IHC of paraffin-embedded Adenocarcinoma of colon tissue using anti-FRK mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded endometrium tissue using anti-FRK mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Adenocarcinoma of colon tissue using anti-FRK mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded endometrium tissue using anti-FRK mouse monoclonal antibody. (Dilution 1:50).

FRK Antibody (Internal) LS-C352208
Rabbit Polyclonal to Human FRK
Rat, Human
ICC IF IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of FRK staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of FRK staining in K562 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Immunohistochemical analysis of FRK staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of FRK staining in K562 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

FRK Antibody (clone 7H3) LS-C114624
Mouse Monoclonal [clone 7H3] (IgG1) to Human FRK
Human
Flo IHC IHC-P WB
Unconjugated
100µl  $335.00
IHC of paraffin-embedded endometrium tissue using anti-FRK mouse monoclonal antibody. (Dilution 1:50).
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FRK (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FRK.
IHC of paraffin-embedded endometrium tissue using anti-FRK mouse monoclonal antibody. (Dilution 1:50).
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FRK (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FRK.

FRK Antibody (aa71-120) LS-C118893
Rabbit Polyclonal (IgG) to Human FRK
Mouse, Rat, Human
IF IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using FRK Antibody. The picture on the right is blocked with the synthesized peptide.
Immunofluorescence analysis of HUVEC cells, using FRK Antibody. The picture on the right is blocked with the synthesized peptide.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using FRK Antibody. The picture on the right is blocked with the synthesized peptide.
Immunofluorescence analysis of HUVEC cells, using FRK Antibody. The picture on the right is blocked with the synthesized peptide.

FRK Antibody LS-C665666
Rabbit Polyclonal (IgG) to Human FRK
Human
ELISA IF IHC WB
Unconjugated
100µg  $335.00

FRK Antibody (40-120 aa, Internal) LS-C385771
Rabbit Polyclonal (IgG) to Human FRK
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Rak antibody
Western blot of Rak antibody

FRK Antibody LS-C675775
Rabbit Polyclonal (IgG) to Human FRK
Human
ELISA IHC IHC-P WB
Unconjugated
50µl  $235.00; 100µl  $285.00
Immunohistochemistry of paraffin-embedded human endometrial cancer at dilution 1:100
Immunohistochemistry of paraffin-embedded human rectum tissue at dilution 1:100
Immunohistochemistry of paraffin-embedded human endometrial cancer at dilution 1:100
Immunohistochemistry of paraffin-embedded human rectum tissue at dilution 1:100

FRK Antibody (Asn103) LS-C176763
Rabbit Polyclonal to Human FRK
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
100µl  $345.00
IHC of Rak (N103) pAb in paraffin-embedded human breast carcinoma tissue.
Western blot of Rak (N103) pAb in extracts from PC12 cells.
IHC of Rak (N103) pAb in paraffin-embedded human breast carcinoma tissue.
Western blot of Rak (N103) pAb in extracts from PC12 cells.

FRK Antibody (clone 3E2) LS-C172340
Mouse Monoclonal [clone 3E2] (IgG1) to Human FRK
Human
Flo IF WB
Unconjugated
100µl 0.92mg/ml  $335.00
Anti-FRK mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FRK.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FRK (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FRK.
Anti-FRK mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FRK.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FRK (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FRK.

FRK Antibody LS-C349239
Rabbit Polyclonal (IgG) to Human FRK
Mouse, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunofluorescence analysis of A549 cells.
Immunofluorescence analysis of A549 cells.
Immunofluorescence analysis of A549 cells.
Immunofluorescence analysis of A549 cells.

FRK Antibody (clone 5F3) LS-C114724
Mouse Monoclonal [clone 5F3] (IgG1) to Human FRK
Human
Flo IF
Unconjugated
100µl  $335.00
Anti-FRK mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FRK.
Immunofluorescent staining of HepG2 cells using anti-FRK mouse monoclonal antibody.
Anti-FRK mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FRK.
Immunofluorescent staining of HepG2 cells using anti-FRK mouse monoclonal antibody.

FRK Antibody LS-C401692
Rabbit Polyclonal (IgG) to Human FRK
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human liver cancer using FRK Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of Human brain using FRK Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of Human liver cancer using FRK Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of Human brain using FRK Polyclonal Antibody at dilution of 1:50.

FRK Antibody LS-C404994
Rabbit Polyclonal (IgG) to Human FRK
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human colon cancer using FRK Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human brain using FRK Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human colon cancer using FRK Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human brain using FRK Polyclonal Antibody at dilution of 1:40.

FRK Antibody (aa1-107) LS-C36374
Rat Monoclonal (IgG1) to Human FRK
Human
ELISA IHC
Unconjugated
100µg 100µl  $620.00

FRK Antibody (N-Terminus) LS-C327403
Rabbit Polyclonal (IgG) to Human FRK
Human
ELISA IHC
Unconjugated
200µl 0.25mg/ml  $530.00

FRK Antibody (N-Terminus, Biotin) LS-C277416
Rabbit Polyclonal (IgG) to Human FRK
Human
ELISA IHC
Biotin Conjugated
200µl  $680.00

FRK Antibody (N-Terminus, FITC) LS-C277417
Rabbit Polyclonal (IgG) to Human FRK
Human
ELISA IHC
FITC Conjugated
200µl  $680.00

FRK Antibody (N-Terminus, AP) LS-C277413
Rabbit Polyclonal (IgG) to Human FRK
Human
ELISA IHC
AP Conjugated
200µl  $680.00

FRK Antibody (N-Terminus, APC) LS-C277415
Rabbit Polyclonal (IgG) to Human FRK
Human
ELISA IHC
APC Conjugated
200µl  $680.00

FRK Antibody (N-Terminus, PE) LS-C277419
Rabbit Polyclonal (IgG) to Human FRK
Human
ELISA IHC
PE Conjugated
200µl  $680.00

FRK Antibody (aa464-491) LS-C321467
Rabbit Polyclonal (IgG) to Mouse FRK
Mouse
ELISA WB
Unconjugated
200µl  $530.00

FRK Antibody (aa234-491) LS-C374811
Rabbit Polyclonal (IgG) to Human FRK
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00; 10ml 0.5mg/ml  $2,100.00
Western blot of FRK antibody.
Western blot of FRK antibody.

FRK Antibody (clone 40) LS-C108818
Mouse Monoclonal [clone 40] (IgG1) to Human FRK
Human
ELISA WB
Unconjugated
100µl  $345.00
Western blot using FRK mouse monoclonal antibody against K562 cell lysate (1).
Western blot using FRK mouse monoclonal antibody against K562 cell lysate (1).
Showing 1-25 of 56 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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