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FREM2 is an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome.
Gene Name: | FRAS1 related extracellular matrix protein 2 |
Synonyms: | FREM2, ECM3 homolog |
Target Sequences: | NP_997244.4 Q5SZK8 |
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