Fragilis / IFITM3

interferon induced transmembrane protein 3

IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

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Products

Antibodies (40)

Type

Primary (40)

Target

Fragilis / IFITM3 (40)

Reactivity

Human (39)

Mouse (5)

Rat (5)

Pig (1)

Application

IHC (8)

IHC-P (4)

WB (37)

Flo (1)

ELISA (14)

ICC (4)

IF (7)

IP (2)

Peptide-ELISA (4)

Host

rabbit (29)

mouse (8)

goat (3)

Product Group

IHCPlus (2)

Isotype

IgG (23)

IgG1 (1)

IgG1,k (7)

Clonality

monoclonal mc (9)

polyclonal pc (31)

Clone

1082CT14.1.3.1 (1)

4C8-1B10 (1)

EPR5242 (1)

Format

APC Conjugated (2)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (2)

Unconjugated (27)

Epitope

N-Terminus (3)

aa1-50 (2)

10-90 aa, N-terminal (1)

Internal (1)

Internal Region (1)

aa1-30 (1)

aa3-57 (1)

aa64-93 (1)

aa9-54 (1)

Publications

No (38)

Yes (2)

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IHC-plus™ Fragilis / IFITM3 Antibody (Internal, clone EPR5242) LS-B7510

(4.0) Rating

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Monoclonal (Internal) (EPR5242) Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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Fragilis / IFITM3 Antibody (N-Terminus) LS-C353254

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Pig, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$299

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Fragilis / IFITM3 Antibody (aa1-30) LS-C98676

(4.0) Rating

(1) Publication(s)

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

400 µl/$393

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Fragilis / IFITM3 Antibody (aa64-93) LS-C98677

(4.0) Rating

(1) Publication(s)

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal (aa64-93) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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Fragilis / IFITM3 Antibody (aa1-50) LS-C119528

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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Fragilis / IFITM3 Antibody (aa1-50) LS-C19391

Antibody:

Fragilis / IFITM3 Rabbit anti-Mouse Polyclonal (aa1-50) Antibody

Reactivity:

Mouse, Rat

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$386

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Fragilis / IFITM3 Antibody LS-C666320

Antibody:

Fragilis / IFITM3 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$371

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IHC-plus™ Fragilis / IFITM3 Antibody LS-B9383

(4.0) Rating

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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Fragilis / IFITM3 Antibody LS-C666319

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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Fragilis / IFITM3 Antibody LS-C404573

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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Fragilis / IFITM3 Antibody LS-C401297

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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Fragilis / IFITM3 Antibody LS-C673232

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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Fragilis / IFITM3 Antibody (10-90 aa, N-terminal) LS-C384055

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal (10-90 aa, N-terminal) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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Fragilis / IFITM3 Antibody LS-C823571

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$357

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Fragilis / IFITM3 Antibody LS-C807101

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Fragilis / IFITM3 Antibody LS-C763502

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$250; 60 µl/$286; 120 µl/$349; 200 µl/$439

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Fragilis / IFITM3 Antibody (clone 4C8-1B10) LS-C308394

Antibody:

Fragilis / IFITM3 Mouse anti-Human Monoclonal (4C8-1B10) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$705

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Fragilis / IFITM3 Antibody (HRP) LS-C542649

Antibody:

Fragilis / IFITM3 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$904

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Fragilis / IFITM3 Antibody (Biotin) LS-C522516

Antibody:

Fragilis / IFITM3 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

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Fragilis / IFITM3 Antibody (FITC) LS-C532560

Antibody:

Fragilis / IFITM3 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

100 µl/$904

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Fragilis / IFITM3 Antibody (PE) LS-C650761

Antibody:

Fragilis / IFITM3 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

100 µl/$904

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Fragilis / IFITM3 Antibody (APC) LS-C514301

Antibody:

Fragilis / IFITM3 Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

100 µl/$904

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC

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Fragilis / IFITM3 Antibody (aa9-54) LS-C313795

Antibody:

Fragilis / IFITM3 Rabbit anti-Human Polyclonal (aa9-54) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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Fragilis / IFITM3 Antibody (Internal Region) LS-C502372

Antibody:

Fragilis / IFITM3 Goat anti-Human Polyclonal (Internal Region) Antibody

Reactivity:

Human

Applications:

IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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Fragilis / IFITM3 Antibody (N-Terminus, clone 1082CT14.1.3.1) LS-C757901

Antibody:

Fragilis / IFITM3 Mouse anti-Human Monoclonal (N-Terminus) (1082CT14.1.3.1) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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