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Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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Additional Contact Details
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FPR2 / FPRL1
formyl peptide receptor 2
FPRL1, a Chemoattractant Receptor also called Lipoxin A4 Receptor, functions as a component of the inflammatory response. Its stimulation results in neutrophil activation and desensitization of chemokine receptors in monocytes (Le et al., 2000). The receptor is up-regulated by interleukin-1 in normal human synovial fibroblasts. The immunodeficiency virus type 1 (HIV-1) envelope protein gp41 can activate the innate host immune cells through FPRL1 and induces directional migration and calcium mobilization in human monocytes and neutrophils. Recently, FPRL1 has been implicated in Alzheimer's Disease.
| Gene Name: | formyl peptide receptor 2 |
| Family/Subfamily: | GPCR , Chemoattractant |
| Synonyms: | FPR2, ALXR, FMLP-R-I, FMLP-related receptor I, Fpr-rs1, FPRL1, FPR-like 1, Fprl-1, HM63, FMLP-R-II, FMLPX, Formyl peptide receptor-like 1, FPR2A, FPRH1, FPRH2, LXA4 receptor, LXA4R, Lipoxin A4 receptor, Lipoxin receptor, N-formyl peptide receptor 2, Formyl peptide receptor 2 |
| Target Sequences: | NM_001462 NP_001453.1 P25090 |
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