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FPGS

folylpolyglutamate synthase

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.

Gene Name: folylpolyglutamate synthase
Synonyms: FPGS, Folylpolyglutamate synthase, Tetrahydrofolate synthase
Target Sequences: NM_004957 NP_004948.4 Q05932

Publications (1)

1
Pharmacogenomics of intracellular methotrexate polyglutamates in patients' leukemia cells in vivo. Elixabet Lopez-Lopez, Robert J Autry, Colton Smith, Wenjian Yang, Steven W Paugh, John C Panetta, Kristine R Crews, Erik J Bonten, Brandon Smart, Deqing Pei, J Robert McCorkle, Barthelemy Diouf, Kathryn G Roberts, Lei Shi, Stanley Pounds, Cheng Cheng, Charles G Mullighan, Ching-Hon Pui, Mary V Relling, William E Evans. The Journal of clinical investigation. 2020 December;130:6600-6615. [Full Text Article] [PubMed:33164984] [PMC:PMC7685728] Related Antibodies: LS-C680494.

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
FPGS (4)
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GST, N-terminus (1)
His-T7 (1)
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E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
FPGS Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
FPGS Protein - Recombinant Folylpolyglutamate Synthase, Mitochondrial By SDS-PAGE
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E. coli
His-T7
29.3 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
FPGS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59 kDa
20 µg/$215
FPGS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).