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20700 44th Avenue W
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FPGS
folylpolyglutamate synthase
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.
| Gene Name: | folylpolyglutamate synthase |
| Synonyms: | FPGS, Folylpolyglutamate synthase, Tetrahydrofolate synthase |
| Target Sequences: | NM_004957 NP_004948.4 Q05932 |
Publications (1)
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