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FPGS

folylpolyglutamate synthase

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.

Gene Name: folylpolyglutamate synthase
Synonyms: FPGS, Folylpolyglutamate synthase, Tetrahydrofolate synthase
Target Sequences: NM_004957 NP_004948.4 Q05932

Publications (1)

1
Pharmacogenomics of intracellular methotrexate polyglutamates in patients' leukemia cells in vivo. Elixabet Lopez-Lopez, Robert J Autry, Colton Smith, Wenjian Yang, Steven W Paugh, John C Panetta, Kristine R Crews, Erik J Bonten, Brandon Smart, Deqing Pei, J Robert McCorkle, Barthelemy Diouf, Kathryn G Roberts, Lei Shi, Stanley Pounds, Cheng Cheng, Charles G Mullighan, Ching-Hon Pui, Mary V Relling, William E Evans. The Journal of clinical investigation. 2020 December;130:6600-6615. [Full Text Article] [PubMed:33164984] [PMC:PMC7685728] Related Antibodies: LS-C680494.

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Antibodies (24)
Primary (24)
FPGS (24)
Human (24)
Mouse (8)
Rat (1)
Chimpanzee (3)
IHC (7)
IHC-P (4)
WB (20)
Flo (1)
ELISA (10)
rabbit (24)
IgG (11)
polyclonal pc (24)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (4)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (6)
aa210-439 (8)
aa304-330 (7)
aa265-314 (4)
No (23)
Yes (1)
FPGS Antibody - Western Blot Positive WB detected in: HepG2 whole cell lysate, MCF-7 whole cell lysate All Lanes: FPGS antibody at 3.2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 65, 61, 60, 62 KDa Observed band size: 65 KDa
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FPGS Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
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FPGS Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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FPGS Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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FPGS Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
FPGS Antibody - Formalin-fixed and paraffin-embedded human lung carcinoma with FPGS Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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FPGS Rabbit anti-Human Polyclonal (aa304-330) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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FPGS Rabbit anti-Human Polyclonal (aa304-330) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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FPGS Rabbit anti-Human Polyclonal (aa304-330) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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FPGS Rabbit anti-Human Polyclonal (aa304-330) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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FPGS Rabbit anti-Human Polyclonal (aa304-330) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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FPGS Rabbit anti-Human Polyclonal (aa304-330) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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FPGS Rabbit anti-Human Polyclonal (aa304-330) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
FPGS Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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FPGS Rabbit anti-Human Polyclonal (aa265-314) Antibody
Human
IHC-P, WB
Unconjugated
100 µl/$424
FPGS Antibody - FPGS antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FPGS Rabbit anti-Human Polyclonal (aa265-314) (HRP) Antibody
Human, Chimpanzee
WB
HRP Conjugated
100 µl/$469
FPGS Antibody - FPGS antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FPGS Rabbit anti-Human Polyclonal (aa265-314) (Biotin) Antibody
Human, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
FPGS Antibody - FPGS antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FPGS Rabbit anti-Human Polyclonal (aa265-314) (FITC) Antibody
Human, Chimpanzee
WB
FITC Conjugated
100 µl/$469
FPGS Antibody - Human prostate smooth muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
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FPGS Rabbit anti-Mouse Polyclonal (aa210-439) Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
FPGS Antibody - Western blot of FPGS antibody.
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FPGS Rabbit anti-Mouse Polyclonal (aa210-439) (HRP) Antibody
Mouse, Human
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
FPGS Antibody - Western blot of FPGS antibody.
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FPGS Rabbit anti-Mouse Polyclonal (aa210-439) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
FPGS Antibody - Western blot of FPGS antibody.
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FPGS Rabbit anti-Mouse Polyclonal (aa210-439) (FITC) Antibody
Mouse, Human
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
FPGS Antibody - Western blot of FPGS antibody.
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FPGS Rabbit anti-Mouse Polyclonal (aa210-439) (APC, Cy7) Antibody
Mouse, Human
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
FPGS Antibody - Western blot of FPGS antibody.
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FPGS Rabbit anti-Mouse Polyclonal (aa210-439) (Cy3) Antibody
Mouse, Human
WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
FPGS Antibody - Western blot of FPGS antibody.
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FPGS Rabbit anti-Mouse Polyclonal (aa210-439) (APC) Antibody
Mouse, Human
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
FPGS Antibody - Western blot of FPGS antibody.
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FPGS Rabbit anti-Mouse Polyclonal (aa210-439) (PE) Antibody
Mouse, Human
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
FPGS Antibody - Immunochemical staining of human FPGS in human kidney with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.
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FPGS Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µl/$412
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).