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FOXP3

forkhead box P3

FOXP3 is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name:	forkhead box P3
Synonyms:	FOXP3, AIID, DIETER, Forkhead box protein P3, JM2, Forkhead box P3, FOXP3delta7, XPID, PIDX, SCURFIN
Target Sequences:	NM_014009 NP_054728.2 Q9BZS1

Publications (5)

Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells. Ochando JC, Yopp AC, Yang Y, Garin A, Li Y, Boros P, Llodra J, Ding Y, Lira SA, Krieger NR, Bromberg JS. Journal of immunology (Baltimore, Md. : 1950). 2005 174:6993-7005. (IHC) [PubMed:15905542]

Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells. Lim HW, Hillsamer P, Banham AH, Kim CH. Journal of immunology (Baltimore, Md. : 1950). 2005 175:4180-3. [PubMed:16177055]

Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory t cells in the granulomatous lesions. Rahman S, Gudetta B, Fink J, Granath A, Ashenafi S, Aseffa A, Derbew M, Svensson M, Andersson J, Brighenti SG. The American journal of pathology. 2009 174:2211-24. [PubMed:19435796] [PMC:PMC2684186]

B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Wilcox RA, Feldman AL, Wada DA, Yang ZZ, Comfere NI, Dong H, Kwon ED, Novak AJ, Markovic SN, Pittelkow MR, Witzig TE, Ansell SM. Blood. 2009 114:2149-58. [PubMed:19597183] [PMC:PMC2744574]

Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment. Sang Jun Han , Nuri Sung , Jin Wang, Bert W O'Malley, David M Lonard. Breast cancer research : BCR. 2022 October;24:73. [Full Text Article] [PubMed:36316775] [PMC:PMC9620627] Related Antibodies: LS-C344878.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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