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FOXO3 / FOXO3A

forkhead box O3

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.

Gene Name: forkhead box O3
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: FOXO3, AF6q21, AF6q21 protein, Forkhead box O3, Forkhead box O3A, FOXO3A, FKHRL1P2, Forkhead box protein O3, FOXO2, FKHRL1
Target Sequences: NM_001455 NP_001446.1 O43524

Publications (1)

1
Impact of miRNA-mRNA Profiling and Their Correlation on Medulloblastoma Tumorigenesis. Kumar V, Kumar V, Chaudhary AK, Coulter DW, McGuire T, Mahato RI. Molecular therapy. Nucleic acids. 2018 September;12:490-503. [Full Text Article] [PubMed:30195786] [PMC:PMC6070673]

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Products
Proteins (12)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (5)
Recombinant (6)
FOXO3 / FOXO3A (12)
No (12)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (1)
His, N-Terminal (2)
His-T7 (1)
Myc-DDK (Flag) (6)
Human (10)
293T Cells (2)
E. coli (2)
HEK 293 Cells (6)
Wheat Germ Extract (2)
Purified (2)
Supernatant (1)
FOXO3 / FOXO3A Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
48.1 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
FOXO3 / FOXO3A Protein - Purified recombinant protein FOXO3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
71.1 kDa
20 µg/$1,107
FOXO3 / FOXO3A Protein - Purified recombinant protein FOXO3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
71.1 kDa
20 µg/$1,107
FOXO3 / FOXO3A Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
FOXO3 / FOXO3A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
71.1 kDa
20 µg/$150
FOXO3 / FOXO3A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
71.1 kDa
20 µg/$150
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HEK 293 Cells
His, N-Terminal
~71 kDa
200 µl/$283
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HEK 293 Cells
His, N-Terminal
~71 kDa
100 µg/$298
FOXO3 / FOXO3A Protein - Recombinant Forkhead Box Protein O3 By SDS-PAGE
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E. coli
His-T7
32.0 kDa
10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142
FOXO3 / FOXO3A Protein - 12.5% SDS-PAGE of human FOXO3 stained with Coomassie Blue
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Wheat Germ Extract
GST
97.7 kDa
2 µg/$439
FOXO3 / FOXO3A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
71.1 kDa
100 µg/$494
FOXO3 / FOXO3A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
71.1 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).