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FOXN1
forkhead box N1
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed.
| Gene Name: | forkhead box N1 |
| Synonyms: | FOXN1, FKHL20, Forkhead box protein N1, Forkhead box N1, WHN, Rowett nude, Winged helix nude, RONU, Winged-helix nude |
| Target Sequences: | NM_003593 NP_003584.2 O15353 |
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