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FOXL2
forkhead box L2
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
| Gene Name: | forkhead box L2 |
| Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
| Synonyms: | FOXL2, BPES, BPES1, Forkhead box L2, Forkhead box protein L2, PFRK, PINTO, POF3 |
| Target Sequences: | NM_023067 NP_075555.1 P58012 |
Publications (2)
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