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FOXC1

forkhead box C1

Forkhead box C1 (FOXC1) belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of FOXC1 has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in FOXC1 cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.

Gene Name: forkhead box C1
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: FOXC1, Forkhead-like 7, FREAC3, FKHL7, Forkhead-related activator 3, Forkhead-related protein FKHL7, IGDA, IHG1, IRID1, Forkhead box protein C1, Mesenchyme fork head protein 1, Myeloid factor-delta, ARA, Forkhead box C1, FREAC-3, RIEG3
Target Sequences: NM_001453 NP_001444.2 Q12948

Publications (1)

1
FOXC1 overexpression is a marker of poor response to anthracycline-based adjuvant chemotherapy in sporadic triple-negative breast cancer. Xu YL, Yao R, Li J, Zhou YD, Mao F, Pan B, Sun Q. Cancer chemotherapy and pharmacology. 2017 June;79:1205-1213. (Human) [Full Text Article] [PubMed:28493031] [PMC:PMC5438824]

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Proteins (5)
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FOXC1 (5)
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GST, N-terminus (1)
GST, N-terminus + His, C-terminus (1)
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293T Cells (1)
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HEK 293 Cells (1)
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FOXC1 Protein
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E. coli
GST, N-terminus + His, C-terminus
84.6 kDa
50 µg/$419
FOXC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
56.6 kDa
20 µg/$215
FOXC1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
FOXC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
56.6 kDa
100 µg/$710
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E. coli
His
16.4 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).