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FOXA3
forkhead box A3
Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.
| Gene Name: | forkhead box A3 |
| Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
| Synonyms: | FOXA3, Forkhead box A3, HNF-3G, HNF3G, HNF-3-gamma, Forkhead box protein A3, TCF3G, TCF-3G, FKHH3, Transcription factor 3G |
| Target Sequences: | NM_004497 NP_004488.2 P55318 |
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