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FOLR3 is a member of the folate receptor (FOLR) family, members of which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene includes two polymorphic variants; the shorter one has two base deletion in the CDS, resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The longer protein has a 71% and 79% sequence homology with the FOLR1 and FOLR2 proteins, respectively.
Gene Name: | folate receptor 3 (gamma) |
Synonyms: | FOLR3, Folate receptor 3 (gamma), Folate receptor gamma, Folate receptor 3, FR-G, FR-gamma, Gamma-hFR |
Target Sequences: | NM_000804 NP_000795.2 P41439 |
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