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FMOD / Fibromodulin

fibromodulin

Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants.

Gene Name: fibromodulin
Synonyms: FMOD, Fibromodulin, Fibromodulin proteoglycan, FM, KSPG fibromodulin, SLRR2E
Target Sequences: NM_002023 NP_002014.2 Q06828

Publications (1)

1
Anchored Fibromodulin as a Novel Target in Chronic Lymphocytic Leukemia: Diagnostic and Therapeutic Implications. Lia Farahi, Fatemeh Ghaemimanesh, Saeideh Milani, Seyed Mohsen Razavi, Reza Hadavi, Ali Ahmad Bayat, Ali Salimi, Mohammad Mehdi Akhondi, Hodjattallah Rabbani. Iranian journal of immunology. 2019 June;16:127-141. [Full Text Article] [PubMed:31182687] Related Antibodies: LS-C677960.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).