FMO3

flavin containing monooxygenase 3

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.

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Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

FMO3 (7)

Publications

No (7)

Tag

GST (1)

Myc-DDK (Flag) (6)

Species

Human (5)

Source

293T Cells (2)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (1)

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FMO3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122625

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.9 kDa

Price:

100 µg/$710

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FMO3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114999

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.9 kDa

Price:

100 µg/$494

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Human FMO3 Protein (Recombinant GST) (Full Length) - LS-G28499

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

86.5 kDa

Price:

2 µg/$439

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Human FMO3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75527

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.9 kDa

Price:

20 µg/$150

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Human FMO3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75526

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.9 kDa

Price:

20 µg/$215

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Human FMO3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65414

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.9 kDa

Price:

20 µg/$1,107

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Human FMO3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65416

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.9 kDa

Price:

20 µg/$1,107

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