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FMO3

flavin containing monooxygenase 3

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.

Gene Name: flavin containing monooxygenase 3
Synonyms: FMO3, DJ127D3.1, FMO 3, FMOII, TMAU, Trimethylamine monooxygenase, Dimethylaniline oxidase 3, FMO form 2, FMO II
Target Sequences: NM_006894 NP_008825.4 P31513

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Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
FMO3 (7)
No (7)
GST (1)
Myc-DDK (Flag) (6)
Human (5)
293T Cells (2)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purified (1)
FMO3 Protein - Purified recombinant protein FMO3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
59.9 kDa
20 µg/$1,024
FMO3 Protein - Purified recombinant protein FMO3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
59.9 kDa
20 µg/$1,005
FMO3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.9 kDa
100 µg/$458
FMO3 Protein - 12.5% SDS-PAGE of human FMO3 stained with Coomassie Blue
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Wheat Germ Extract
GST
86.5 kDa
2 µg/$429
FMO3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.9 kDa
100 µg/$607
FMO3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59.9 kDa
20 µg/$130
FMO3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
59.9 kDa
20 µg/$200
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).