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FMO2
flavin containing monooxygenase 2 (non-functional)
FMO2 is a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants.
| Gene Name: | flavin containing monooxygenase 2 (non-functional) |
| Synonyms: | FMO2, Dimethylaniline oxidase 2, FMO 2, FMO1B1, FMO 1B1, FMO, pulmonary |
| Target Sequences: | NM_001460 NP_001451.2 Q99518 |
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