FLT1 / VEGFR1

fms-related tyrosine kinase 1

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.

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Products

Proteins (13)

Type

Recombinant (13)

Target

FLT1 / VEGFR1 (13)

Publications

No (13)

Tag

DDK,C-terminus (1)

Fc, C-terminus (2)

GST, N-terminus (1)

His (3)

His, N-Terminal (1)

His-GST, N-terminus (2)

His-S (1)

His-T7 (1)

Myc-DDK (Flag) (1)

Species

Human (7)

Mouse (1)

Pig (2)

Rat (3)

Source

E. coli (5)

HEK 293 Cells (1)

Human Cells (4)

Mammalian Cells (1)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (5)

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Pig FLT1 / VEGFR1 Protein (Recombinant His-GST, N-terminus) (Pro167-Ala424) - LS-G14335

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

60.9 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Human FLT1 / VEGFR1 Protein (Recombinant Fc, C-terminus) (Ser27-Asn756) - LS-G40051

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

109kD

Price:

10 µg/$277; 50 µg/$395; 500 µg/$1,203; 1 mg/$1,627

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Human FLT1 / VEGFR1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66998

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

148 kDa

Price:

20 µg/$1,107

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Human FLT1 / VEGFR1 Protein (Recombinant GST, N-terminus) (aa581-687) - LS-G58590

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human FLT1 / VEGFR1 Protein (Recombinant His) (Met1-Ile328) - LS-G97480

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

35.6 kDa

Price:

100 µg/$721

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Pig FLT1 / VEGFR1 Protein (Recombinant His-GST, N-terminus) (Lys19-Leu146) - LS-G14333

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

41.9 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Rat FLT1 / VEGFR1 Protein (Recombinant His-S) (aa303-524) - LS-G14336

Source:

E. coli

Tag:

His-S

Molecular Weight:

30.7 kDa

Price:

10 µg/$274; 50 µg/$400; 100 µg/$637; 200 µg/$797; 1 mg/$1,870; 500 µg/$1,424; 5 mg/$2,832; 2 mg/$2,053

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Mouse FLT1 / VEGFR1 Protein (Recombinant His, N-Terminal) (Ser27-Val329) - LS-G14328

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

35.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Rat FLT1 / VEGFR1 Protein (Recombinant His-T7) (aa18-308) - LS-G24511

Source:

E. coli

Tag:

His-T7

Molecular Weight:

36.3 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

Select

Human FLT1 / VEGFR1 Protein (Recombinant Fc, C-terminus) (Ser27-Asn756) - LS-G139218

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

109.0 kDa

Price:

10 µg/$277; 50 µg/$389

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Human FLT1 / VEGFR1 Protein (Recombinant DDK,C-terminus) - LS-G142363

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

82.4 kDa

Price:

20 µg/$677

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Rat FLT1 / VEGFR1 Protein (Recombinant His) (Met1-Glu758) - LS-G98396

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

84 kDa

Price:

100 µg/$532

Select

Human FLT1 / VEGFR1 Protein (Recombinant His) (Met1-Asn756) - LS-G98685

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

83.7 kDa

Price:

100 µg/$721; 1 mg/$4,192

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