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FLNA / Filamin A

filamin A, alpha

FLNA / Filamin A is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: filamin A, alpha
Synonyms: FLNA, ABPX, Actin binding protein 280, Actin-binding protein 280, Filamin A, FLN1, FMD, Filamin-A, Filamin-1, FLN, FLN-A, Non-muscle filamin, OPD1, OPD2, Alpha-filamin, NHBP, OPD, XMVD, CVD1, Filamin A, alpha, MNS, XLVD
Target Sequences: NM_001456 NP_001447.2 P21333

Publications (1)

1
Potential Utility of Protein Targets of Cysteine-S-Nitrosylation in Identifying Clinical Disease Status in Human Chagas Disease. Maria Paola Zago, John E Wiktorowicz, Heidi Spratt, Sue-Jie Koo, Natalia Barrientos, Aida Nuñez Burgos, Julio Nuñez Burgos, Facundo Iñiguez, Valentina Botelli, Ricardo Leon de la Fuente, Nisha Jain Garg. Frontiers in microbiology. 2019 January;9:3320. [Full Text Article] [PubMed:30697201] [PMC:PMC6340995]

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
FLNA / Filamin A (5)
No (5)
6His-T7, N-terminus (1)
GST (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
FLNA / Filamin A Protein - Purified recombinant protein FLNA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
280.6 kDa
20 µg/$1,107
FLNA / Filamin A Protein - Recombinant  Filamin A Alpha By SDS-PAGE
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E. coli
6His-T7, N-terminus
34.3 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
FLNA / Filamin A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
279.8 kDa
20 µg/$215
FLNA / Filamin A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
279.8 kDa
100 µg/$710
FLNA / Filamin A Protein - 12.5% SDS-PAGE of human FLNA stained with Coomassie Blue
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Wheat Germ Extract
GST
117.92 kDa
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).