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FKBP6

FK506 binding protein 6, 36kDa

Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.

Gene Name: FK506 binding protein 6, 36kDa
Synonyms: FKBP6, 36 kDa FK506-binding protein, 36 kDa FKBP, FK506-binding protein 6 (36kD), FKBP-36, FKBP-6, FKBP36, Immunophilin FKBP36, FK506-binding protein 6, Rotamase, PPIase, PPIase FKBP6, FK506 binding protein 6, 36kDa
Target Sequences: NM_003602

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).