FKBP4 / FKBP52

FK506 binding protein 4, 59kDa

FKBP4 / FKBP52 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

FKBP4 / FKBP52 (9)

Publications

No (9)

Tag

6His, C-terminus (2)

GST (1)

GST, N-terminus (1)

His (1)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (3)

Biologically Active

Biologically active (1)

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Human FKBP4 / FKBP52 Protein (Recombinant His) - LS-G525

Source:

E. coli

Tag:

His

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

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FKBP4 / FKBP52 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118239

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.6 kDa

Price:

100 µg/$494

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Human FKBP4 / FKBP52 Protein (Recombinant GST) (Full Length) - LS-G28482

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

76.12 kDa

Price:

10 µg/$479; 25 µg/$670

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Human FKBP4 / FKBP52 Protein (Recombinant His-GST) (aa2-459) - LS-G25491

Source:

E. coli

Tag:

His-GST

Molecular Weight:

81.7 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Human FKBP4 / FKBP52 Protein (Recombinant GST, N-terminus) (aa301-410) - LS-G58572

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human FKBP4 / FKBP52 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66512

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.6 kDa

Price:

20 µg/$1,107

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Human FKBP4 / FKBP52 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77883

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.6 kDa

Price:

20 µg/$150

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Human FKBP4 / FKBP52 Protein (Recombinant 6His, C-terminus) (Met1-Ala459) - LS-G138795

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

52.8 kDa

Price:

10 µg/$332; 50 µg/$376

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Human FKBP4 / FKBP52 Protein (Recombinant 6His, C-terminus) (Met1-Ala459) - LS-G39760

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

52.8kD

Price:

10 µg/$243; 50 µg/$288; 500 µg/$1,262; 1 mg/$1,627

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