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FKBP38 / FKBP8

FK506 binding protein 8, 38kDa

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Gene Name: FK506 binding protein 8, 38kDa
Synonyms: FKBP8, 38 kDa FKBP, 38 kDa FK506-binding protein, FKBP-8, FK506-binding protein 8, FKBP38, HFKBP38, FKBP-38, Rotamase, FK506 binding protein 8, 38kDa, FK506-binding protein 8 (38kD), FKBPr38, PPIase FKBP8
Target Sequences: NM_012181 NP_036313.3 Q14318

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
FKBP38 / FKBP8 (5)
No (5)
GST (1)
His (2)
Myc-DDK (Flag) (2)
Human (3)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
FKBP38 / FKBP8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
44.5 kDa
20 µg/$150
FKBP38 / FKBP8 Protein - Recombinant FK506 Binding Protein 8 By SDS-PAGE
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E. coli
His
25.7 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
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E. coli
His
28.6 kDa
10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
FKBP38 / FKBP8 Protein - 12.5% SDS-PAGE of human FKBP8 stained with Coomassie Blue
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Wheat Germ Extract
GST
64.79 kDa
10 µg/$479; 25 µg/$670
FKBP38 / FKBP8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
44.5 kDa
100 µg/$494
Viewing 1-5 of 5 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).