Fibrinogen

Fibrinogen (factor I) is a glycoprotein in vertebrates that helps in the formation of blood clots. It consists of a linear array of three nodules held together by a very thin thread which is estimated to have a diameter between 8 and 15 Angstrom (Å). The two end nodules are alike but the center one is slightly smaller. Measurements of shadow lengths indicate that nodule diameters are in the range 50 to 70 Angstrom. The length of the dried molecule is 475 ± 25 Angstrom. The fibrinogen molecule is a soluble, large, and complex glycoprotein, 340 kDa plasma glycoprotein, that is converted by thrombin into fibrin during blood clot formation. It has a rod-like shape with dimensions of 9 × 47.5 × 6 nm and it shows a negative net charge at physiological pH (IP at pH 5.2). Fibrinogen is synthesized in the liver by the hepatocytes. The concentration of fibrinogen in the blood plasma is 200–400 mg/dL (normally measured using the Clauss method). During normal blood coagulation, a coagulation cascade activates the zymogen prothrombin by converting it into the serine protease thrombin. Thrombin then converts the soluble fibrinogen into insoluble fibrin strands. These strands are then cross-linked by factor XIII to form a blood clot. FXIIa stabilizes fibrin further by incorporation of the fibrinolysis inhibitors alpha-2-antiplasmin and TAFI (thrombin activatable fibrinolysis inhibitor, procarboxypeptidase B), and binding to several adhesive proteins of various cells. Both the activation of factor XIII by thrombin and plasminogen activator (t-PA) are catalyzed by fibrin. Fibrin specifically binds the activated coagulation factors factor Xa and thrombin and entraps them in the network of fibers, thus functioning as a temporary inhibitor of these enzymes, which stay active and can be released during fibrinolysis.

Fibrinogen Target Details

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Proteins (5)

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Native (3)

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (1)

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Fibrinogen (5)

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No (5)

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6His, N-terminus (2)

His, N-Terminal (2)

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Cow (1)

Human (4)

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HEK 293 Cells (2)

Mammalian Cells (2)

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Purified (2)

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Human Fibrinogen Protein (Over-Expression Lysate 6His, N-terminus) (Ala20-Arg271) - LS-G26802

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

92.5 kDa

Price:

100 µg/$298

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Human Fibrinogen Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Ala20-Arg271) - LS-G26938

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

92.5 kDa

Price:

200 µl/$283

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Human Fibrinogen Protein (Native) - LS-G37576

Tag:

None

Molecular Weight:

340 kD

Price:

25 mg/$327

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Human Fibrinogen Protein (Native His, N-Terminal) - LS-G133087

Source:

Mammalian Cells

Tag:

His, N-Terminal

Molecular Weight:

70/56/52kDa

Price:

10 µg/$227; 50 µg/$251; 200 µg/$291; 100 µg/$275; 1 mg/$602; 500 µg/$402; 5 mg/$1,237; 2 mg/$702

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Cow Fibrinogen Protein (Native His, N-Terminal) - LS-G133095

Source:

Mammalian Cells

Tag:

His, N-Terminal

Price:

10 µg/$280; 50 µg/$432; 200 µg/$865; 100 µg/$692; 1 mg/$1,966; 500 µg/$1,510; 5 mg/$3,025; 2 mg/$2,153

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