Fibrinogen

Fibrinogen (factor I) is a glycoprotein in vertebrates that helps in the formation of blood clots. It consists of a linear array of three nodules held together by a very thin thread which is estimated to have a diameter between 8 and 15 Angstrom (Å). The two end nodules are alike but the center one is slightly smaller. Measurements of shadow lengths indicate that nodule diameters are in the range 50 to 70 Angstrom. The length of the dried molecule is 475 ± 25 Angstrom. The fibrinogen molecule is a soluble, large, and complex glycoprotein, 340 kDa plasma glycoprotein, that is converted by thrombin into fibrin during blood clot formation. It has a rod-like shape with dimensions of 9 × 47.5 × 6 nm and it shows a negative net charge at physiological pH (IP at pH 5.2). Fibrinogen is synthesized in the liver by the hepatocytes. The concentration of fibrinogen in the blood plasma is 200–400 mg/dL (normally measured using the Clauss method). During normal blood coagulation, a coagulation cascade activates the zymogen prothrombin by converting it into the serine protease thrombin. Thrombin then converts the soluble fibrinogen into insoluble fibrin strands. These strands are then cross-linked by factor XIII to form a blood clot. FXIIa stabilizes fibrin further by incorporation of the fibrinolysis inhibitors alpha-2-antiplasmin and TAFI (thrombin activatable fibrinolysis inhibitor, procarboxypeptidase B), and binding to several adhesive proteins of various cells. Both the activation of factor XIII by thrombin and plasminogen activator (t-PA) are catalyzed by fibrin. Fibrin specifically binds the activated coagulation factors factor Xa and thrombin and entraps them in the network of fibers, thus functioning as a temporary inhibitor of these enzymes, which stay active and can be released during fibrinolysis.

Fibrinogen Target Details

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Products

ELISA Kits (33)

Type

Competitive EIA (1)

Sandwich (29)

Sandwich CLIA (3)

Target

Fibrinogen (33)

Reactivity

Human (9)

Mouse (7)

Rat (3)

Bovine (1)

Canine (1)

Chicken (1)

Goat (1)

Guinea pig (2)

Monkey (1)

Pig (4)

Rabbit (2)

Sheep (1)

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Format

12 x 8-Well Microstrips (4)

96-Well Microplate (3)

96-Well Strip Plate (26)

Publications

No (32)

Yes (1)

Sample Type

Plasma (29)

Serum (21)

Tissue Homogenates (7)

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Rat Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F22517

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

62.5 - 4000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$771

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Human Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F10413

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

3.125 - 800 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$531

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Rabbit Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F10457

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(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.5 - 500 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$896

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Mouse Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F10440

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

3.125 - 800 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$556

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Pig Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F6323

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.14 - 100 µg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma

Price:

1 Plate/$889

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Bovine Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F6449

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Bovine

Range:

3.9 - 250 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma

Price:

1 Plate/$889

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Monkey Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F38513

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Monkey

Range:

9.38 - 600 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$682

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Human Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F56334

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Pig Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F10455

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

1.56 - 800 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$743

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Rabbit Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F43852

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.375 - 24 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F22853

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

9.38 - 600 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$724

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Mouse Fibrinogen (CLIA) ELISA Kit - LS-F30673

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

7.813 - 500 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Mouse Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F28688

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

50 - 1000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

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Pig Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F36787

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Tissue Homogenates

Price:

1 Plate/$579

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Rat Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F10459

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

3.125 - 800 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$556

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Chicken Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F43845

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

62.5 - 4000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Guinea pig Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F43848

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

125 - 8000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Guinea pig Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F43849

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

125 - 8000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Sheep Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F43854

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

31.25 - 2000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$760

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Human Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F51872

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 µg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$958

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Mouse Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F53088

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 µg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$870

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Human Fibrinogen (Competitive EIA) ELISA Kit - LS-F55411

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

370.4 - 30000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma

Price:

1 Plate/$764

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Mouse Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F56068

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.625 - 1000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Goat Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F56282

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Goat

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse Fibrinogen (Sandwich ELISA) ELISA Kit - LS-F25153

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

62.5 - 4000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma

Price:

1 Plate/$782

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