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FGG / Fibrinogen Gamma

fibrinogen gamma chain

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Gene Name: fibrinogen gamma chain
Synonyms: FGG, Fibrinogen gamma-b chain, Fibrinogen gamma chain, Fibrinogen, gamma polypeptide
Target Sequences: NM_021870 NP_068656.2 P02679

Publications (2)

1
Compression force sensing regulates integrin aIIbß3adhesive function on diabetic platelets. Ju L, McFadyen JD, Al-Daher S, Alwis I, Chen Y, Tønnesen LL, Maiocchi S, Coulter B, Calkin AC, Felner EI, Cohen N, Yuan Y, Schoenwaelder SM, Cooper ME, Zhu C, Jackson SP. Nature communications. 2018 March;9:1087. (Human) [Full Text Article] [PubMed:29540687] [PMC:PMC5852038] Related Antibodies: LS-C418056.
2
A novel urinary biomarker protein panel to identify children with ureteropelvic junction obstruction - A pilot study. Charan Kumar V Devarakonda, Emily R Shearier, Chaoran Hu, James Grady, Jeremy L Balsbaugh, John H Makari, Fernando A Ferrer, Linda H Shapiro. Journal of pediatric urology. 2020 Aug;;16:466.e1-466.e9. [Full Text Article] [PubMed:32620509] [PMC:PMC7529974]

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Proteins (12)
Over-Expression Lysate (2)
Recombinant (10)
FGG / Fibrinogen Gamma (12)
No (12)
GST, N-terminus (1)
His (6)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Bovine (1)
Chicken (1)
Human (7)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (7)
Eukaryotic cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
FGG / Fibrinogen Gamma Protein
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E. coli
His
20 µg/$361; 100 µg/$739; 4 µg/$261
FGG / Fibrinogen Gamma Protein - Recombinant  Fibrinogen Gamma By SDS-PAGE
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E. coli
His-T7
35.1 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
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293T Cells
Myc-DDK (Flag)
49.5 kDa
20 µg/$150
FGG / Fibrinogen Gamma Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
FGG / Fibrinogen Gamma Protein - Purified recombinant protein FGG was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
46.4 kDa
20 µg/$1,107
FGG / Fibrinogen Gamma Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
49.5 kDa
100 µg/$494
FGG / Fibrinogen Gamma Protein - Eukaryotic Fibrinogen Gamma (FGg) by SDS-PAGE
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Eukaryotic cells
His, N-Terminal
30kDa
10 µg/$284; 50 µg/$462; 200 µg/$922; 100 µg/$737; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
FGG / Fibrinogen Gamma Protein - Recombinant Fibrinogen Gamma By SDS-PAGE
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E. coli
His
48.5 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
Select
E. coli
His
29.9 kDa
10 µg/$274; 50 µg/$400; 100 µg/$637; 200 µg/$797; 1 mg/$1,870; 500 µg/$1,424; 5 mg/$2,832; 2 mg/$2,053
FGG / Fibrinogen Gamma Protein
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E. coli
His
29.8 kDa
10 µg/$303; 50 µg/$462; 100 µg/$692
FGG / Fibrinogen Gamma Protein - Recombinant Fibrinogen Gamma By SDS-PAGE
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E. coli
His
28.6 kDa
10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107
Select
E. coli
His
31.1 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).